| dc.contributor.author | González-Manan, Daniel [Univ Mayor, Fac Ciencias, Nucleo Quim & Bioquim] | es_CL |
| dc.contributor.author | Barrera, Cynthia | es_CL |
| dc.contributor.author | Valenzuela, Rodrigo | es_CL |
| dc.contributor.author | Rincon, Miguel A. | es_CL |
| dc.contributor.author | Espinosa, Alejandra | es_CL |
| dc.contributor.author | López-Arana, Sandra | es_CL |
| dc.contributor.author | Romero, Nalda | es_CL |
| dc.contributor.author | Vargas, Romina | es_CL |
| dc.contributor.author | Videla, Luis A. | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:37:46Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:37:46Z | |
| dc.date.issued | 2020 | es_CL |
| dc.identifier.citation | Barrera, C., Valenzuela, R., Rincón, M. A., Espinosa, A., López-Arana, S., González-Mañan, D., ... & Videla, L. A. (2020). Iron-induced derangement in hepatic Δ-5 and Δ-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil. Prostaglandins, Leukotrienes and Essential Fatty Acids, 153, 102058. | es_CL |
| dc.identifier.issn | 0952-3278 | es_CL |
| dc.identifier.issn | 1532-2823 | es_CL |
| dc.identifier.uri | https://doi.org/10.1016/j.plefa.2020.102058 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6474 | |
| dc.description.abstract | The administration of iron induces liver oxidative stress and depletion of long-chain polyunsaturated fatty acids (LCPUFAs), n-6/n-3 LCPUFA ratio enhancement and fat accumulation, which may be prevented by antioxidant-rich extra virgin olive oil (AR-EVOO) supplementation. Male Wistar rats were subjected to a control diet (50 mg iron/kg diet) or iron-rich diet (IRD; 200 mg/kg diet) with alternate AR-EVOO for 21 days. Liver fatty acid (FA) analysis was performed by gas-liquid chromatography (GLC) after lipid extraction and fractionation, besides Delta-5 desaturase (Delta-5 D) and Delta 6-D mRNA expression (qPCR) and activity (GLC) measurements. The IRD significantly (p < 0.05) increased hepatic total fat, triacylglycerols, free FA contents and serum transaminases levels, with diminution in those of n-6 and n-3 LCPUFAs, higher n-6/n-3 ratios, lower unsaturation index and Delta 5-D and Delta 6-D activities, whereas the mRNA expression of both desaturases was enhanced over control values, changes that were prevented by concomitant AR-EVOO supplementation. N-6 and n-3 LCPUFAs were also decreased by IRD in extrahepatic tissues and normalized by AR-EVOO. In conclusion, AR-EVOO supplementation prevents IRD-induced changes in parameters related to liver FA metabolism and steatosis, an effect that may have a significant impact in the treatment of iron-related pathologies or metabolic disorders such as non-alcoholic fatty liver disease. | es_CL |
| dc.description.sponsorship | [11140174]; [1191682] | es_CL |
| dc.description.sponsorship | The authors are grateful to grants 11140174 (Initiation FONDECYT to RV) and 1191682 (Regular FONDECYT to NR) for supporting this study. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | ELSEVIER SCI LTD | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Prostaglandins Leukot. Essent. Fatty Acids, FEB, 2020. 153 | |
| dc.subject | Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism | es_CL |
| dc.title | Iron-induced derangement in hepatic Delta-5 and Delta-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000518490100005 | es_CL |
| umayor.indexado | PMID: 32007744 | es_CL |
| dc.identifier.doi | DOI: 10.1016/j.plefa.2020.102058 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q3 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 96 H | es_CL |