| dc.contributor.author | Ahumada, Manuel [Univ Mayor, Fac Ciencias, Ctr Nanotecnol Aplicada] | es_CL |
| dc.contributor.author | Lazurko, Caitlin; Khatoon, Zohra; Goel, Keshav; Sedlakova, Veronika; Cimenci, Cagla Eren; Zhang, Li; Mah, Thien-Fah; Franco, Walfre; Suuronen, Erik J.; Alarcón, Emilio, I | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:37:47Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:37:47Z | |
| dc.date.issued | 2020 | es_CL |
| dc.identifier.citation | Lazurko, C., Khatoon, Z., Goel, K., Sedlakova, V., Eren Cimenci, C., Ahumada, M., ... & Alarcon, E. I. (2019). Multifunctional Nano & Collagen-Based Therapeutic Materials for Skin Repair. ACS Biomaterials Science & Engineering. | es_CL |
| dc.identifier.issn | 2373-9878 | es_CL |
| dc.identifier.uri | https://doi.org/10.1021/acsbiomaterials.9b01281 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6478 | |
| dc.description.abstract | A novel strategy is needed for treating nonhealing wounds, which is able to simultaneously eradicate pathogenic bacteria and promote tissue regeneration. This would improve patient outcome and reduce the number of lower limb amputations. In this work, we present a multifunctional therapeutic approach able to control bacterial infections, provide a protective barrier to a full-thickness wound, and improve wound healing in a clinically relevant animal model. Our approach uses a nanoengineered antimicrobial nanoparticle for creating a sprayable layer onto the wound bed that prevents bacterial proliferation and also eradicates preformed biofilms. As a protective barrier for the wound, we developed a thermoresponsive collagen-based matrix that has prohealing properties and is able to fill wounds independent of their geometries. Our results indicate that using a combination of the matrix with full-thickness microscopic skin tissue columns synergistically contributed to faster and superior skin regeneration in a nonhealing wound model in diabetic mice. | es_CL |
| dc.description.sponsorship | Natural Sciences and Engineering Research Council (NSERC)Natural Sciences and Engineering Research Council of Canada [RGPIN-2015-0632]; Canadian Institutes of Health Sciences (CIHR)Canadian Institutes of Health Research (CIHR); Ministry of Economic Development, Job Creation and Trade; CONICYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) [11180616] | es_CL |
| dc.description.sponsorship | This work was made possible by funding from the Natural Sciences and Engineering Research Council (NSERC) RGPIN-2015-0632 to EIA and the Canadian Institutes of Health Sciences (CIHR) to EIA and EJS. EIA thanks the support of the Ministry of Economic Development, Job Creation and Trade for an Early Researcher Award. MA thanks CONICYT for"FONDECYT de IniciaciOn a la InvestigaciOn"grant no. 11180616. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | AMER CHEMICAL SOC | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | ACS Biomater. Sci. Eng., FEB, 2020. 6(2): p. 1124-1134 | |
| dc.subject | Materials Science, Biomaterials | es_CL |
| dc.title | Multifunctional Nano and Collagen-Based Therapeutic Materials for Skin Repair | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO white journal (El archivo no está formalmente admitido). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000513086900031 | es_CL |
| umayor.indexado | SIN PMID | es_CL |
| dc.identifier.doi | DOI: 10.1021/acsbiomaterials.9b01281 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 28 H | es_CL |