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Impaired IRE1 alpha/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjogren's syndrome patients
(OXFORD UNIV PRESS, 2018)
Objectives. Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1 alpha (IRE1 ...
Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjogren's syndrome patients
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018)
Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial salivary glands (LSG) ...
Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded protein response contribute to autoimmunity? A critical review on Sjogren's syndrome
(ELSEVIER SCIENCE BV, 2018)
For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the importance of target ...