| dc.contributor.author | SanMartin, Carol D. [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Santiago, Chile] | es_CL |
| dc.contributor.author | Rogers, Nicole K. | es_CL |
| dc.contributor.author | Romero, César | es_CL |
| dc.contributor.author | Ponce, Daniela P. | es_CL |
| dc.contributor.author | Salech, Felipe | es_CL |
| dc.contributor.author | López, Mercedes N. | es_CL |
| dc.contributor.author | Gleisner, Alejandra | es_CL |
| dc.contributor.author | Tempio, Fabian | es_CL |
| dc.contributor.author | Behrens, María I. | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:37:49Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:37:49Z | |
| dc.date.issued | 2020 | es_CL |
| dc.identifier.citation | Rogers, N. K., Romero, C., SanMartín, C. D., Ponce, D. P., Salech, F., López, M. N., ... & Behrens, M. I. (2019). Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases. Journal of Alzheimer's Disease, (Preprint), 1-12. | es_CL |
| dc.identifier.issn | 1387-2877 | es_CL |
| dc.identifier.issn | 1875-8908 | es_CL |
| dc.identifier.uri | https://doi.org/10.3233/JAD-190839 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6502 | |
| dc.description.abstract | Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the adult population. There is evidence of an inverse epidemiological relationship between AD and cancer, another prevalent age-related disease. This has led to hypothesize that there could be a common biological mechanism, deregulated in opposite directions that might explain the phenomenon of mutual protection. The immunological system and its regulatory checkpoints are good candidates to explain why having survived a cancer could protect from developing AD. During cancerous growth, the neoplastic cells induce immune tolerance to block the host's immunity system that would prevent tumor growth. This has led to the development of drugs that block distinct immune checkpoints, such as Programmed Death 1 (PD-1) and its major ligand PD-L1, that have shown great promise in treating diverse types of cancer. We propose that in those individuals who survived a cancer, the immune system is left in a state of diminished tolerance or proinflammatory systemic milieu, after its successful attempt to fight the cancer, that protects them from developing AD. | es_CL |
| dc.description.sponsorship | FONDECYT (Fondo de Desarrollo Cientifico y Tecnologico) [1151297, 1190958 11171061, 3170917, IMII P09/16-F] | es_CL |
| dc.description.sponsorship | This work was supported by FONDECYT (Fondo de Desarrollo Cientifico y Tecnologico) Grants: 1151297, 1190958 11171061, 3170917, Proyecto IMII P09/16-F. | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | IOS PRESS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | J. Alzheimers Dis., 2020. 73(2): p. 443-454 | |
| dc.subject | Neurosciences | es_CL |
| dc.title | Inverse Relationship Between Alzheimer's Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases | es_CL |
| dc.type | Revisión | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000512318900002 | es_CL |
| umayor.indexado | PMID: 31839609 | es_CL |
| dc.identifier.doi | DOI: 10.3233/JAD-190839 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q2 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 115 H | es_CL |