| dc.contributor.author | Rivera, Daniela S. [Univ Mayor, GEMA Ctr Genom Ecol & Environm] | es_CL |
| dc.contributor.author | Lindsay, Carolina B. | es_CL |
| dc.contributor.author | Zolezzi, Juan M. | es_CL |
| dc.contributor.author | Cisternas, Pedro | es_CL |
| dc.contributor.author | Bozinovic, Francisco | es_CL |
| dc.contributor.author | Inestrosa, Nibaldo C. | es_CL |
| dc.date.accessioned | 2020-04-12T14:11:55Z | |
| dc.date.accessioned | 2020-04-14T15:37:53Z | |
| dc.date.available | 2020-04-12T14:11:55Z | |
| dc.date.available | 2020-04-14T15:37:53Z | |
| dc.date.issued | 2020 | es_CL |
| dc.identifier.citation | Lindsay, C. B., Zolezzi, J. M., Rivera, D. S., Cisternas, P., Bozinovic, F., & Inestrosa, N. C. (2020). Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus. Molecular Neurobiology, 57(2), 1131-1145. | es_CL |
| dc.identifier.issn | 0893-7648 | es_CL |
| dc.identifier.issn | 1559-1182 | es_CL |
| dc.identifier.uri | https://doi.org/10.1007/s12035-019-01784-6 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/6540 | |
| dc.description.abstract | Alzheimer's disease (AD) is a devastating neurodegenerative disorder in which superior brain functions, such as memory and cognition, are impaired. Currently, no effective treatment is available for AD. Although andrographolide (ANDRO), a compound extracted from the herb Andrographis paniculata, has shown interesting effects in models of several diseases, including AD, its effects on other molecular changes observed in AD, such as neuroinflammation and oxidative stress, have not yet been studied. To evaluate the impact of ANDRO-based intervention on the levels of amyloid-beta (A beta) and neuroinflammatory and oxidative stress markers in the brains of aged Octodon degus, a Chilean rodent, fifty-six-month-old O. degus were treated intraperitoneally with 2 or 4 mg/kg ANDRO. Vehicle-injected and 12-month-old O. degus were used as positive controls. Then, the protein levels of selected markers were assessed via immunohistochemistry and immunoblotting. ANDRO significantly reduced the total A beta burden as well as astrogliosis and interleukin-6 levels. Moreover, ANDRO significantly reduced the levels of 4-hydroxynonenal and N-tyrosine adducts, suggesting a relevant reduction in oxidative stress within aged O. degus brain. Considering that O. degus has been proposed as a potential"natural"model for sporadic AD due to the development of neuropathological markers that resemble this pathology, our results suggest that ANDRO should be further studied to establish its potential as a therapeutic drug for AD. | es_CL |
| dc.description.sponsorship | FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [3,140,395, 11,160,651]; Basal Center of Excellence in Science and TechnologyComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT PIA/BASAL [CONICYT PIA/BASAL FB0002, CONICYT-AFB 170005, FB 0002-2014]; Basal Center of Excellence in Science and Technology (FONDECYT) [1,160,724] | es_CL |
| dc.description.sponsorship | This work was supported by a postdoctoral grant from FONDECYT (No 3,140,395 to DSR and No 11,160,651 to PC) and by grants from the Basal Center of Excellence in Science and Technology (CONICYT PIA/BASAL FB0002 to FB 0002-2014 (Line 3), CONICYT-AFB 170005 and FONDECYT No 1,160,724 to NCI). | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | SPRINGER | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
| dc.source | Mol. Neurobiol., FEB, 2020. 57(2): p. 1131-1145 | |
| dc.subject | Neurosciences | es_CL |
| dc.title | Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus | es_CL |
| dc.type | Artículo | es_CL |
| umayor.facultad | CIENCIAS | |
| umayor.politicas.sherpa/romeo | RoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.php | es_CL |
| umayor.indexado | WOS:000495033800004 | es_CL |
| umayor.indexado | PMID: 31701436 | es_CL |
| dc.identifier.doi | DOI: 10.1007/s12035-019-01784-6 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 96 H | es_CL |