| dc.contributor | Chile. Universidad Mayor | es |
| dc.contributor.author | Catalán, Mabel | |
| dc.contributor.author | Castro-Castillo, Vicente | |
| dc.contributor.author | Gajardo-de la Fuente, Javier | |
| dc.contributor.author | Ferreira, Jorge | |
| dc.contributor.author | Olmedo, Ivonne | |
| dc.contributor.author | Molina-Berrios, Alfredo | |
| dc.contributor.author | Aguilera, Jocelyn | |
| dc.contributor.author | Palominos, Charlotte | |
| dc.contributor.author | Valencia, Marcelo | |
| dc.contributor.author | Domínguez, Marta | |
| dc.contributor.author | Ramires-Fernandez, Ricardo [Chile. Universidad Mayor] | |
| dc.contributor.author | Souto, José A. | |
| dc.contributor.author | Jara, José A. | |
| dc.date.accessioned | 2021-03-01T20:21:25Z | |
| dc.date.available | 2021-03-01T20:21:25Z | |
| dc.date.issued | 2020-10-01 | |
| dc.identifier.citation | Catalán, M., Castro-Castillo, V., Gajardo-de la Fuente, J., Aguilera, J., Ferreira, J., Ramires-Fernandez, R., Olmedo, I., Molina-Berríos, A., Palominos, C., Valencia, M., Domínguez, M., Souto, J. A., & Jara, J. A. (2020). Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines. RSC medicinal chemistry, 11(10), 1210–1225. https://doi.org/10.1039/d0md00153h | es |
| dc.identifier.issn | eISSN: 2632-8682 | |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/7382 | |
| dc.identifier.uri | https://doi.org/10.1039/d0md00153h | |
| dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2020/MD/D0MD00153H#!divAbstract | |
| dc.description.abstract | Continuous flow chemistry was used for the synthesis of a series of delocalized lipophilic triphenylphosphonium cations (DLCs) linked by means of an ester functional group to several hydroxylated benzoic acid derivatives and evaluated in terms of both reaction time and selectivity. The synthesized compounds showed cytotoxic activity and selectivity in head and neck tumor cell lines. The mechanism of action of the molecules involved a mitochondrial uncoupling effect and a decrease in both intracellular ATP production and apoptosis induction. | es |
| dc.description.sponsorship | This work was supported by U-INICIA grant from the Vicerrectoria de Investigacion y Desarrollo, Universidad de Chile. [Grant U-INICIA-2014-82379] (JAJ), Fondecyt Iniciacion Grant No. 11180533 (JAJ), Fondecyt Iniciacion grant No. 11160281 (MC), Fondecyt Iniciacion Grant No. 11170962 and Fondecyt Regular grant No. 1180296 (JF and JAJ). | es |
| dc.format.extent | 16 p., PDF | es |
| dc.language.iso | en_US | es |
| dc.publisher | Royal Society of Chemistry | es |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es |
| dc.source | RSC medicinal chemistry, 11(10), 1210–1225 | |
| dc.subject | IN-VIVO | es |
| dc.subject | DERIVATIVES | es |
| dc.subject | RESISTANCE | es |
| dc.subject | BATCH | es |
| dc.title | Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines | es |
| dc.type | Artículo o Paper | es |
| umayor.indizador | COT | es |
| umayor.politicas.sherpa/romeo | Licence CC BY-NC. Disponible en: https://v2.sherpa.ac.uk/id/publication/18023 | es |
| umayor.indexado | Web of Science | es |
| umayor.indexado | WOS:000582620900008 | |
| umayor.indexado | PMID: 33479625 | |
| dc.identifier.doi | 10.1039/d0md00153h | |