Browsing Centro de Biología Integrativa (CBI) by Author "Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]"

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Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Gorostieta-Salas, Elisa; Moreno-Blas, Daniel; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cisneros, Bulmaro; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castro-Obregón, Susana (HINDAWI LTD, 2021-08-16)

Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such ...
IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation

Gómora-García, Juan Carlos; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Pérez-Martínez, Xochitl; Massieu, Lourdes (SPRINGER NATURE, 2021-06-03)

Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the ...