Browsing Centro de Biología Integrativa (CBI) by Author "Geschwind, Daniel"

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Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Geronimo-Olvera, Cristian [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Girardi, Karina [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Necuñir-Ibarra, David [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Kumar Patel, Sandip; Bons, Joanna; Wright, Megan C.; Geschwind, Daniel; Hoke, Ahmet; Gómez-Sánchez, José A.; Schilling, Birgit; Rebolledo, Daniela L. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile]; Campisi, Judith; Court, Felipe A. [Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Chile] (Wiley-Blackwell, 2023-12-07)

Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c-Jun transcription factor activation. ...