Now showing items 1-2 of 2

    • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival 

      Cárdenas, César [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Urra, Felix; Mizzoni, Craig; Ahumada-Castro, Ulises; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Jana, Fabián; Cruz, Pablo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Farías, Paula [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Mendoza, Elizabeth [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Huerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Murgas, Paola [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Hunter, Martin; Róos, Melany [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cerda, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgo, Jordi; Foskett, J. Kevin (American Association for the Advancement of Science, 2020-07)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging 

      Sanhueza, Mario [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Court, Felipe A. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Santiago, Chile]; Mueller, Marioly; Ahumada-Castro, Ulises; González-Billault, Christian; Cárdenas, César (FRONTIERS MEDIA SA, 2018)
      Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several age-dependent neurodegenerative diseases and may be a major contributing factor in ...


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