• Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network 

      Letelier, Joaquín [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile]; Buono, Lorena; Almuedo-Castillo, María; Zang, Jingjing; Mounieres, Constanza [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile]; González-Diaz, Sergio; Polvillo, Rocío; Sanabria-Reinoso, Estefanía; Corbacho, Jorge; Sousa-Ortega, Ana; del Corral, Ruth Diez; Neuhauss, Stephan C. F.; Martínez-Morales, Juan R. (eLIFE SCIENCES PUBL LTD, 2023-05-25)
      early function in progenitors' specification, and a later requirement for bipolar-cells fate determination. Despite their conserved expression patterns, it is currently unclear to which extent Vsx functions are also conserved ...
    • Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease 

      Salech, Felipe; Ponce, Daniela P.; Paula-Lima, Andrea C.; SanMartin, Carol D. [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile]; Behrens, Maria I. (Frontiers Media S.A., 2020-08)
      Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal development, survival and death. Numerous data suggest that ...
    • The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging 

      Muñoz-Carvajal, Francisco [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile]; Sanhueza, Mario [Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Chile] (Frontiers Media S.A., 2020-09)
      Aging is the time-dependent functional decline that increases the vulnerability to different forms of stress, constituting the major risk factor for the development of neurodegenerative diseases. Dysfunctional mitochondria ...


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