Listar Papers publicados por CBI por autor "Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile"
Mostrando ítems 1-19 de 19
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Association of Vitamin D Receptor Polymorphisms with Amyloid-β Transporters Expression and Risk of Mild Cognitive Impairment in a Chilean Cohort
Rogers, Nicole K.; Farias, Gonzalo; Delgado, Carolina; Henriquez, Mauricio; Herrera, Luisa; Behrens, Maria; Arevalo, Nohela B. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castillo-Godoy, Daniela P. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Espinoza-Fuenzalida, Italo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; SanMartin, Carol D. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Escuela Tecnol Med, Escuela Biotecnol, Chile] (IOS PRESS, 2021-07-15)Background: Amyloid-beta peptide (A beta) deposition in Alzheimer's disease (AD) is due to an imbalance in its production/clearance rate. Ap is transported across the blood-brain barrier by LRP1 and P-gp as efflux transporters ... -
Axonal Degeneration in AD: The Contribution of A beta and Tau
Salvadores, Natalia [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Geronimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Frontiers Media S.A., 2020-10)Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder, affecting around 35 million people worldwide. Despite enormous efforts dedicated to AD research over decades, there is still no ... -
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival
Cárdenas, César [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Urra, Felix; Mizzoni, Craig; Ahumada-Castro, Ulises; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Jana, Fabián; Cruz, Pablo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Farías, Paula [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Mendoza, Elizabeth [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Huerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Murgas, Paola [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Hunter, Martin; Róos, Melany [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cerda, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgo, Jordi; Foskett, J. Kevin (American Association for the Advancement of Science, 2020-07)Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ... -
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile
Lemaitre, Dominique; Llavero Hurtado, Maica; De Gregorio, Cristian; Onate, Maritza; Martínez, Gabriela; Catenaccio, Alejandra [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Wishart, Thomas M.; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Humana Press, 2020-10)Peripheral nerve injuries result in motor and sensory dysfunction which can be recovered by compensatory or regenerative processes. In situations where axonal regeneration of injured neurons is hampered, compensation by ... -
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria
Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Ahumada-Castro, Ulises [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Farias, Paula [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Gonzalez-Billault, Christian [Univ Mayor, Fac Sci, Gerosci Ctr Brain Hlth & Metab, Chile]; Molgo, Jordi; Cardenas, Cesar [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Frontiers Media S.A., 2020-05)Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca(2+)regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously ... -
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain
Gorostieta-Salas, Elisa; Moreno-Blas, Daniel; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cisneros, Bulmaro; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Castro-Obregón, Susana (HINDAWI LTD, 2021-08-16)Brain aging is characterized by dysfunctional autophagy and cellular senescence, among other features. While autophagy can either promote or suppress cellular senescence in proliferating cells, in postmitotic cells, such ... -
GERO Cohort Protocol, Chile, 2017-2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly
Slachevsky, Andrea; Zitko, Pedro; Martínez-Pernia, David; Forno, Gonzalo; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lillo, Patricia; Villagra, Roque; Durán-Aniotz, Claudia; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibañez, Agustín; Parra, Mario A.; Gonzalez-Billault, Christian; Amieva, Helena; Thumala, Daniela (BioMed Central Ltd., 2020-12)BackgroundWith the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and ... -
Implications of Selective Autophagy Dysfunction for ALS Pathology
Vicencio, Emiliano [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Beltrán, Sebastián [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Labrador, Luis [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Manque, Patricio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Nassif, Melissa [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Woehlbier, Ute [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (MDPI Multidisciplinary Digital Publishing Institute, 2020-02)Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. ... -
In Vivo Antitumor Effect against Murine Cells of CT26 Colon Cancer and EL4 Lymphoma by Autologous Whole Tumor Dead Cells
Barrera-Avalos, Carlos; Diaz, Ximena; Madrid, Bastian; Michelson, Sofia A.; Robles-Planells, Claudia; Sanchez-Guerrero, Giselle; Ahumada, Viviana; Mella-Torres, Andrea; Rojo, Leonel E.; Imarai, Monica; Milla, Luis A.; Leiva-Salcedo, Elias; Fernandez, Ricardo; Escobar, Alejandro; Acuña-Castillo, Claudio; Murgas, Paola [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (HINDAWI LTD, 2021-03-14)Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific immune responses. Immunization strategies using whole dead cells from tumor tissue, containing ... -
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells
Cruz, Pablo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Ahumada-Castro, Ulises [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Bustos, Galdo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Molgo, Jordi; Sauma, Daniela; Lovy, Alenka [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cárdenas, Cesar [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (MDPI, 2021-01)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial ... -
Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer
Zhang, Yu; Chandra, Vidhi; Riquelme Sanchez, Erick [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Dutta, Prasanta; Quesada, Pompeyo R.; Rakoski, Amanda; Zoltan, Michelle; Arora, Nivedita; Baydogan, Seyda; Horne, William; Burks, Jared; Xu, Hanwen; Hussain, Perwez; Wang, Huamin; Gupta, Sonal; Maitra, Anirban; Bailey, Jennifer M.; Moghaddam, Seyed J.; Banerjee, Sulagna; Sahin, Ismet; Bhattacharya, Pratip; McAllister, Florencia (Rockefeller University Press, 2020-12)Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive ... -
IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation
Gómora-García, Juan Carlos; Gerónimo-Olvera, Cristian [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Pérez-Martínez, Xochitl; Massieu, Lourdes (SPRINGER NATURE, 2021-06-03)Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the ... -
Keeping zombies alive: The ER-mitochondria Ca2+ transfer in cellular senescence
Ahumada-Castro, Ulises [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Puebla-Huerta, Andrea [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cuevas-Espinoza, Victor [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lovy, Alenka [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cesar Cardenas, J. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (ELSEVIER, 2021-08-31)Cellular senescence generates a permanent cell cycle arrest, characterized by apoptosis resistance and a pro-inflammatory senescence-associated secretory phenotype (SASP). Physiologically, senescent cells promote tissue ... -
Levels of low-molecular-weight hyaluronan in periodontitis-treated patients and its immunostimulatory effects on CD4+ T lymphocytes
Castillo, Francisca; Monasterio, Gustavo; Ibarra, Juan; Guevara, José; Cafferata, Emilio A.; Carvajal, Paola; Vernal, Rolando; Vicencio, Emiliano [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Cortez, Cristian [Univ Mayor, Fac Sci, Ctr Genom & Bioinformat, Chile] (SPRINGER HEIDELBERG, 2021-02-26)Objectives During periodontitis, chronic inflammation triggers soft tissue breakdown, and hyaluronan is degraded into fragments of low molecular weight (LMW-HA). This investigation aimed to elucidate whether LMW-HA fragments ... -
Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction
Alvizi, Lucas; Nani, Diogo; Brito, Luciano Abreu; Kobayashi, Gerson Shigeru; Passos-Bueno, Maria Rita; Mayor, Roberto [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Nature Publishing Group, 2023-05-24)Gene-environment interactions are believed to play a role in multifactorial phenotypes, although poorly described mechanistically. Cleft lip/palate (CLP), the most common craniofacial malformation, has been associated with ... -
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells
Pérez-Moreno, Pablo; Quezada-Meza, Camila; Chavez-Almarza, Cristopher; Niechi, Ignacio; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Trigo-Hidalgo, César; Aguayo, Francisco; Jara, Lilian; Cáceres-Verschae, Albano; Varas-Godoy, Manuel; Díaz, Víctor M.; García de Herreros, Antonio; Burzio, Veronica A.; Tapia, Julio C. (Frontiers Media S.A., 2020-07)Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ... -
Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells
Aguilera-Herce, Julia; Panadero-Medianero, Concepción [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Sánchez-Romero, María Antonia; Balbontín, Roberto; Bernal-Bayard, Joaquín; Ramos-Morales, Francisco (MDPI, 2023-05-07)Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. Salmonella enterica has two type III secretion systems associated with virulence, one involved in the invasion of ... -
SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells
Krabbendam, Inge E.; Honrath, Birgit; Bothof, Laura; Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Huerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Penaranda Fajardo, Natalia M.; Dekker, Frank; Schmidt, Martina; Culmsee, Carsten; Cardenas, César Julio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Kruyt, Frank; Dolga, Amalia M. (Elsevier Inc., 2020-01)Brain tumours are among the deadliest tumours being highly resistant to currently available therapies. The proliferative behaviour of gliomas is strongly influenced by ion channel activity. Small-conductance calcium-activated ... -
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?
Salvadores, Natalia [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile] (Taylor and Francis Ltd., 2020-07)Introduction: Necroptosis is a programmed form of necrotic cell death. Growing evidence demonstrates that necroptosis contributes to cell demise in different pathological conditions including age-dependent neurodegenerative ...