Listar Centro de Investigación en Genómica y Bioinformática (CGB) por autor "Public Library of Science"
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Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
Kalempa Demeu, Lara Maria; Soares, Rodrigo Jahn; Miranda, Juliana Severo; Pacheco-Lugo, Lisandro A.; Oliveira, Kelin Goncalves; Cortez Plaza, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Billiald, Philippe; de Moura, Juliana Ferreira; Yoshida, Nobuko; Alvarenga, Larissa Magalhaes; DaRocha, Wanderson Duarte (Chile. Universidad Mayor, 2019-10-16)Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ... -
The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains
Hernández-Guerrero, Rafael; Galán-Vásquez, Edgardo; Pérez-Rueda, Ernesto [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (Public Library of Science, 2019-12-19)In this work, we describe a systematic comparative genomic analysis of promiscuous domains in genomes of Bacteria and Archaea. A quantitative measure of domain promiscuity, the weighted domain architecture score (WDAS), ...