• A balancing act: how plants integrate nitrogen and water signals 

      Araus, Viviana; Swift, Joseph; Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henry, Amelia; Coruzzi, Gloria M. (Oxford University Press, 2020-07-25)
      Nitrogen (N) and water (W) are crucial inputs for plant survival as well as costly resources for agriculture. Given their importance, the molecular mechanisms that plants rely on to signal changes in either N or W status ...
    • A decade later, reviewing floating marine debris in Northern Chilean Patagonia 

      Ahrendt, C.; DeCoite, M.; Pulgar, J.; Pozo, K.; Hinojosa, I. A.; Galban-Malagon, C. [Univ Mayor, GEMA Ctr Genom Ecol & Environm, Chile] (PERGAMON-ELSEVIER SCIENCE LTD, 2021-07-07)
      Floating marine debris (FMD) were abundantly reported in the Northern Chilean Patagonia in 2009 where seabased activities (mussel and salmon aquaculture) are responsible for most of them. Identifying the sources of FMD is ...
    • A dynamic portal for a community-driven, continuously updated classification of Fungi and fungus-like organisms: outlineoffungi.org 

      Madrid, H. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Wijayawardene, N. N.; Hyde, K. D.; Dai, D. Q.; Tang, L. Z.; Aptroot, A.; Castaneda-Ruiz, R. F.; Druzhinina, I. S.; Cai, F.; Ekanayaka, A. H.; Erdogdu, M.; Fiuza, P. O.; Gentekaki, E.; Goto, B. T.; Haelewaters, D.; Hongsanan, S.; Jeewon, R.; Kirk, P. M.; Jayalal, R. G. U.; Karunarathna, S. C.; Wanasinghe, D. N.; Lumbsch, H. T.; Maharachchikumbura, S. S. N.; Monteiro, J. S.; Shivaprakash, N.; Pfliegler, W. P.; Phillips, A. J. L.; Saxena, R. K.; Stadler, M.; Tian, Q.; Tokarev, Y. S.; Tsurykau, A.; Ertz, D.; Lee, H. B.; Etayo, J.; Vizzini, A.; Jones, E. B. G.; Lin, C. G.; Li, W. J.; Dai, Y. C.; Fan, X. L.; McKenzie, E. H. C.; Shivas, R. G.; Hustad, V.; Leontyev, D., V.; de Hoog, G. S.; Niskanen, T.; Boekhout, T.; Gaya, E.; Thines, M. (Chile. Universidad Mayor, 2020)
      The website http://outlineoffungi.org, is launched to provide a continuous up-to-date classification of the kingdom Fungi (including fossil fungi) and fungus-like taxa. This is based on recent publications and on the outline ...
    • A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues 

      Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Li, Yong; Martonfalvi, Zsolt; Tapia-Rojo, Rafael; Unger, Andreas; Fernández-Trasancos, Angel; Herrero-Galán, Elías; Velázquez-Carreras, Diana; Fernández, Julio M.; Linke, Wolfgang A.; Alegre-Cebollada, Jorge (Nature Publishing Group, 2020-04-28)
      Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ...
    • A Revised View of the LSU Gene Family: New Functions in Plant Stress Responses and Phytohormone Signaling 

      Canales, Javier; Arenas-M, Anita; Medina, Joaquín; Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (MDPI, 2023-02)
      LSUs (RESPONSE TO LOW SULFUR) are plant-specific proteins of unknown function that were initially identified during transcriptomic studies of the sulfur deficiency response in Arabidopsis. Recent functional studies have ...
    • AciDB 1.0: a database of acidophilic organisms, their genomic information and associated metadata 

      Neira, Gonzalo; Cortez, Diego; Jil, Joaquín; Holmes, David S. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Investigación de Genómica y Bioinformática] (OXFORD UNIV PRESS, 2020-10-01)
      Motivation: There are about 600 available genome sequences of acidophilic organisms (grow at a pH<5) from the three domains of the Tree of Life. Information about acidophiles is scattered over many heterogeneous sites ...
    • Anaerobic RSH-dependent tellurite reduction contributes to Escherichia coli tolerance against tellurite 

      Muñoz-Diaz, P.; Jiménez, K.; Luraschi, R.; Cornejo, F.; Figueroa, M.; Vera, C.; Rivas-Pardo, A. [Univ Mayor, Ctr Genom & Bioinformat, Lab Genom Microbiana, Chile]; Sandoval, J. M.; Vásquez, C.; Arenas, F. (SOC BIOLGIA CHILE, 2022-03)
      Background Tellurium is a rare metalloid that exerts high toxicity on cells, especially on bacteria, partly due to reactive oxygen species (ROS) generation. Moreover, it has also been observed that tellurite can target ...
    • ATP6V(0)d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis 

      Cortez, Cristián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Pessoa, Carina Carraro; Reis, Luiza Campos; Ramos-Sánchez, Eduardo Milton; Orikaza, Cristina Mary; de Castro Levatti, Erica Valadares; Benites Badaro, Ana Carolina; da Silva Yamamoto, Joyce Umbelino; D'Almeida, Vania; Goto, Hiro; Mortara, Renato Arruda; Real, Fernando (PUBLIC LIBRARY SCIENCE, 2019)
      V-ATPases are part of the membrane components of pathogen-containing vacuoles, although their function in intracellular infection remains elusive. In addition to organelle acidification, V-ATPases are alternatively implicated ...
    • Bacterially produced metabolites protect C. elegans neurons from degeneration 

      Urrutia, Arles; García-Angulo, Víctor A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Fuentes, Andres [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Caneo, Mauricio; Legue, Marcela [Univ Mayor, Fac Ciencias, Ctr Genom Integrat, Chile]; Urquiza, Sebastian [Univ Mayor, Fac Ciencias, Ctr Genom Integrat, Chile]; Delgado, Scarlett E. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Ugalde, Juan [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Burdisso, Paula; Calixto, Andrea [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (Public Library of Science, 2020-03)
      Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains ...
    • Bioinformatic analyses of unique (orphan) core genes of the genus Acidithiobacillus: Functional inferences and use as molecular probes for genomic and metagenomic/transcriptomic interrogation 

      González, Carolina [Chile. Universidad Andres Bello. Facultad de Ciencias Biológicas]; Lazcano, Marcelo [Chile. Universidad Andres Bello. Facultad de Ciencias Biológicas]; Valdés, Jorge [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Holmes, David S. [Chile. Universidad Andres Bello. Facultad de Ciencias Biológicas] (Facultad de Ciencias, 2016)
      Using phylogenomic and gene compositional analyses, five highly conserved gene families have been detected in the core genome of the phylogenetically coherent genus Acidithiobacillus of the class Acidithiobacillia. These ...
    • Cátedras del Futuro: C. elegans: ¿cómo un gusano nos puede ayudar a comprender mejor enfermedades como el Parkinson y el Alzheimer? 

      Calixto, Andrea [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Genómica y Bioinformática] (Chile. Universidad Mayor, 2019-09-05)
      En una nueva fecha del ciclo de charlas “Cátedras del Futuro”, la Dra. Andrea Calixto, académica del Centro de Genómica y Bioinformática U. Mayor, que presentó los resultados de las investigaciones que durante 4 años ha ...
    • Cátedras del Futuro: ¿Cambiemos el mundo? Un genoma a la vez 

      Manque, Patricio [Chile. Universidad Mayor] (Chile. Universidad Mayor, 2019-06-26)
      La segunda fecha de este ciclo de conferencias tuvo como protagonista al Dr. Patricio Manque, Vicerrector de Investigación, quien presenta la charla “¿Cambiemos el mundo? Un genoma a la vez”. La jornada, llevada a cabo el ...
    • Chloropicophyceae, a new class of picophytoplanktonic prasinophytes 

      Lopes dos Santos, Adriana [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Pollina, Thibaut; Gourvil, Priscillia; Corre, Erwan; Marie, Dominique; Luis Garrido, José; Rodríguez, Francisco; Noel, Mary-Helene; Vaulot, Daniel; Eikrem, Wenche (Chile. Universidad Mayor, 2016)
      Prasinophytes are a paraphyletic group of nine lineages of green microalgae that are currently classified either at the class or order level or as clades without formal taxonomic description. Prasinophyte clade VII comprises ...
    • Comparative genomics sheds light on transcription factor-mediated regulation in the extreme acidophilic Acidithiobacillia representatives 

      Sepúlveda-Rebolledo, Pedro [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; González-Rosales, Carolina; Dopson, Mark; Pérez-Rueda, Ernesto; Holmes, David S.; Valdés, Jorge H. (Elsevier Masson s.r.l., 2024-01)
      Extreme acidophiles thrive in acidic environments, confront a multitude of challenges, and demonstrate remarkable adaptability in their metabolism to cope with the ever-changing environmental fluctuations, which encompass ...
    • ConnecTF: A platform to integrate transcription factor-gene interactions and validate regulatory networks 

      Brooks, Matthew D.; Juang, Che-Lun; Katari, Manpreet Singh; Pasquino, Angelo; Shih, Hung-Jui; Huang, Ji; Shanks, Carly; Cirrone, Jacopo; Coruzzi, Gloria M.; Alvarez, Jose M. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile] (OXFORD UNIV PRESS INC, 2021-04-28)
      Deciphering gene regulatory networks (GRNs) is both a promise and challenge of systems biology. The promise lies in identifying key transcription factors (TFs) that enable an organism to react to changes in its environment. ...
    • Deciphering the functional diversity of DNA-binding transcription factors in Bacteria and Archaea organisms 

      Flores-Bautista, Emanuel; Hernández-Guerrero, Rafael; Huerta-Saquero, Alejandro; Tenorio-Salgado, Silvia; Rivera-Gómez, Nancy; Romero, Alba; Antonio Ibarra, José; Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile] (Public Library of Science, 2020-08)
      DNA-binding Transcription Factors (TFs) play a central role in regulation of gene expression in prokaryotic organisms, and similarities at the sequence level have been reported. These proteins are predicted with different ...
    • Deep Sequencing Reveals the Complete Genome and Evidence for Transcriptional Activity of the First Virus-Like Sequences Identified in Aristotelia chilensis (Maqui Berry) 

      Rojas-Herrera, Marcelo [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Sanchez, Carolina [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Undurraga, Soledad F. [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Manque, Patricio [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Maracaja-Coutinho, Vinicius [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Polanco, Víctor [Chile. Universidad Mayor. Centro de Genómica y Bioinformática] (CIENCIAS, 2015)
      Here, we report the genome sequence and evidence for transcriptional activity of a virus-like element in the native Chilean berry tree Aristotelia chilensis. We propose to name the endogenous sequence as Aristotelia chilensis ...
    • DEF8 and Autophagy-Associated Genes are Altered in Mild Cognitive Impairment, Probable Alzheimer’s Disease Patients and a Transgenic Model of the Disease 

      Leyton, Esteban [Chile. Universidad Mayor. Centro de Biología Integrativa]; Matus, Diego [Chile. Universidad Mayor. Centro de Biología Integrativa]; Espinoza, Sandra [Chile. Universidad Mayor. Centro de Biología Integrativa]; Benítez, José Matías [Chile. Universidad Mayor. Centro de Biología Integrativa]; Cortés, Bastián [Chile. Universidad Mayor. Centro de Biología Integrativa]; Gómez, Wileidy [Chile. Universidad Mayor. Centro de Biología Integrativa]; Arévalo, Nohela B. [Chile. Universidad Mayor. Centro de Biología Integrativa]; Murgas, Paola [Chile. Universidad Mayor. Centro de Biología Integrativa]; Manque Ramírez, Patricio [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]; Woehlbier, Ute [Chile. Universidad Mayor. Centro de Biología Integrativa]; Durán-Aniotz, Claudia; Hetz, Claudio; Behrens, María Isabel; San Martín, Carol D. [Chile. Universidad Mayor. Centro de Biología Integrativa]; Nassif, Melissa [Chile. Universidad Mayor. Centro de Biología Integrativa] (IOS Press, 2021-02-19)
      Background:Disturbances in the autophagy/endolysosomal systems are proposed as early signatures of Alzheimer’s disease (AD). However, few studies are available concerning autophagy gene expression in AD patients. Objective:To ...
    • Development of a Multiplex PCR Assay for Genotyping the Fish Pathogen Piscirickettsia salmonis Through Comparative Genomics 

      Isla, Adolfo; Martínez-Hernández, J. Eduardo [Univ Mayor, Ctr Genom & Bioinformat, Fac Ciencias, Laboratorio Biol Redes, Chile]; Levipan, Héctor A.; Haussmann, Denise; Figueroa, Jaime; Rauch, María Cecilia; Maracaja-Coutinho, Vinicius; Yáñez, Alejandro (FRONTIERS MEDIA SA, 2021-07-11)
      Piscirickettsia salmonis is a bacterial pathogen that severely impact the aquaculture in several countries as Canada, Scotland, Ireland, Norway, and Chile. It provokes Piscirickettsiosis outbreaks in the marine phase of ...
    • Dormant but Active: Chilling Accumulation Modulates the Epigenome and Transcriptome ofPrunus aviumDuring Bud Dormancy 

      Rothkegel, Karin; Sandoval, Paula; Soto, Esteban; Ulloa, Lissette; Riveros, Anibal; Lillo-Carmona, Victoria; Caceres-Molina, Javier; Almeida, Andrea Miyasaka [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Chile]; Meneses, Claudio (Frontiers Media S.A., 2020-07)
      Temperate deciduous fruit tree species like sweet cherry (Prunus avium) require long periods of low temperatures to trigger dormancy release and flowering. In addition to sequence-based genetic diversity, epigenetic variation ...


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