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dc.contributorUniv Mayor, Fac Sci, Ctr Integrat Biol, Chilees
dc.contributorUniv Mayor, Fac Sci, Gerosci Ctr Brain Hlth & Metab, Chilees
Autordc.contributor.authorKrabbendam, Inge E.
Autordc.contributor.authorHonrath, Birgit
Autordc.contributor.authorBothof, Laura
Autordc.contributor.authorSilva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]
Autordc.contributor.authorHuerta, Hernán [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]
Autordc.contributor.authorPenaranda Fajardo, Natalia M.
Autordc.contributor.authorDekker, Frank
Autordc.contributor.authorSchmidt, Martina
Autordc.contributor.authorCulmsee, Carsten
Autordc.contributor.authorCardenas, César Julio [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]
Autordc.contributor.authorKruyt, Frank
Autordc.contributor.authorDolga, Amalia M.
Fecha registrodc.date.accessioned2022-03-28T15:29:02Z
Fecha disponibledc.date.available2022-03-28T15:29:02Z
Año de Publicacióndc.date.issued2020-01
dc.identifier.citationKrabbendam, I. E., Honrath, B., Bothof, L., Silva-Pavez, E., Huerta, H., Fajardo, N. M. P., ... & Dolga, A. M. (2020). SK channel activation potentiates auranofin-induced cell death in glio-and neuroblastoma cells. Biochemical Pharmacology, 171, 113714.es
dc.identifier.issn0006-2952
dc.identifier.issneISSN: 1873-2968
dc.identifier.otherWOS: 000519219000020
dc.identifier.otherPMID: 31738894
dc.identifier.otherScopus: 2-s2.0-85075469783
URL directadc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/8397
URL directadc.identifier.urihttps://pure.rug.nl/ws/files/103511886/SK_channel_activation_potentiates_auranofin_induced_cell_death_in_glio_and_neuroblastoma_cells_Elsevier_Enhanced_Reader.pdf
URL directadc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0006295219304137?via%3Dihub
URL directadc.identifier.urihttps://doi.org/10.1016/j.bcp.2019.113714
URL directadc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/31738894/
Resumendc.description.abstractBrain tumours are among the deadliest tumours being highly resistant to currently available therapies. The proliferative behaviour of gliomas is strongly influenced by ion channel activity. Small-conductance calcium-activated potassium (SK/K-Ca) channels are a family of ion channels that are associated with cell proliferation and cell survival. A combined treatment of classical anti-cancer agents and pharmacological SK channel modulators has not been addressed yet. We used the gold-derivative auranofin to induce cancer cell death by targeting thioredoxin reductases in combination with CyPPA to activate SK channels in neuro- and glioblastoma cells. Combined treatment with auranofin and CyPPA induced massive mitochondrial damage and potentiated auranofin-induced toxicity in neuroblastoma cells in vitro. In particular, mitochondrial integrity, respiration and associated energy generation were impaired. These findings were recapitulated in patient-derived glioblastoma neurospheres yet not observed in non-cancerous HT22 cells. Taken together, integrating auranofin and SK channel openers to affect mitochondrial health was identified as a promising strategy to increase the effectiveness of anti-cancer agents and potentially overcome resistance.es
dc.description.sponsorshipThe authors thank the Molecular Pharmacology group of University of Groningen for providing scientific and technical support during the experiments. This research was supported by FONDECYT, Chile #1160332 (awarded to J.C.C), CONICYT/FONDAP, Chile #15150012 (awarded to J.C.C). A.M.D. is the recipient of a Rosalind Franklin Fellowship co-funded by the European Union and the University of Groningen, The Netherlands.es
dc.format.extent13 p., PDFes
Idiomadc.language.isoen_USes
Editordc.publisherElsevier Inc.es
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees
Titulodc.titleSK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cellses
Tipo Documentodc.typeArtículo o Paperes
umayor.indizadorCOTes
umayor.politicas.sherpa/romeoLicence CC BYCC BY-NC-ND 4.0. Disponible en: https://v2.sherpa.ac.uk/id/publication/15490es
umayor.indexadoWeb of Sciencees
umayor.indexadoScopuses
umayor.indexadoPUBMEDes
dc.identifier.doi10.1016/j.bcp.2019.113714
umayor.indicadores.wos-(cuartil)Q1
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 198 H
umayor.indicadores.scopus-(scimago-sjr)SJR 1.6


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