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The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling
(NATURE PUBLISHING GROUP, 2019)Pathogenic variants of OPA1, which encodes a dynamin GTPase involved in mitochondrial fusion, are responsible for a spectrum of neurological disorders sharing optic nerve atrophy and visual impairment. To gain insight on ... -
The Microbial Composition in Circumneutral Thermal Springs from Chignahuapan, Puebla, Mexico Reveals the Presence of Particular Sulfur-Oxidizing Bacterial and Viral Communities
(MDPI AG, 2020-11)Terrestrial thermal springs are widely distributed globally, and these springs harbor a broad diversity of organisms of biotechnological interest. In Mexico, few studies exploring this kind of environment have been described. ... -
The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging
(Frontiers Media S.A., 2020-09)Aging is the time-dependent functional decline that increases the vulnerability to different forms of stress, constituting the major risk factor for the development of neurodegenerative diseases. Dysfunctional mitochondria ... -
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
(NATURE PUBLISHING GROUP, 2020-04)Parkinson's disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ... -
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?
(Taylor and Francis Ltd., 2020-07)Introduction: Necroptosis is a programmed form of necrotic cell death. Growing evidence demonstrates that necroptosis contributes to cell demise in different pathological conditions including age-dependent neurodegenerative ... -
The negative effect of lianas on tree growth varies with tree species and seasonPalavras-chave
(Wiley-Blackwell, 2020-05)Lianas reduce tree growth, reproduction, and survival in tropical forests. Liana competition can be particularly intense in isolated forest fragments, where liana densities are high, and thus, host tree infestation is ... -
The Oculome Panel Test: Next-Generation Sequencing to Diagnose a Diverse Range of Genetic Developmental Eye Disorders
(ELSEVIER SCIENCE INC, 2019)Purpose: To develop a comprehensive next-generation sequencing panel assay that screens genes known to cause developmental eye disorders and inherited eye disease and to evaluate its diagnostic yield in a pediatric cohort ... -
THE ORGANIZATIONAL CULTURE AND VALUES ALIGNMENT MANAGEMENT IMPORTANCE FOR SUCCESSFUL BUSINESS
(Chile. Universidad Mayor, 2017)The main objective of this study was to carry out an organizational culture diagnosis in a shipyard, verifying the alignment degree between personal and organizational values. For data collection, a structured questionnaire ... -
The origin and emplacement of Domo Tinto, Guallatiri volcano, Northern Chile.
(CIENCIAS, 2014)El volcán Guallatiri (18°25'S, 69°05'W) es un edificio volcánico ubicado en el Altiplano del norte de Chile, cercano a la frontera con Bolivia. Este volcán, construido en el Pleistoceno-Holoceno en el extremo sur de la ... -
The p75(NTR) neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability
(BMC, 2019)The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression ... -
The Palgrave Handbook of Gender and Migration: Migración y género: investigadora edita libro que fue destacado en Europa
(Chile. Universidad Mayor, 2021-03-19)La académica de la Facultad de Humanidades e investigadora del Centro Sociedad Tecnológica y Futuro Humano de la U. Mayor, Claudia Mora, fue parte del equipo internacional que publicó "The Palgrave Handbook of Gender and ... -
The perceptions of students and teachers regarding the fifth grade english multicultural class
(Chile. Universidad Mayor, 2017-01-01)La siguiente investigación presenta un análisis acerca de la percepción que los estudiantes y profesores poseen acerca de la clase multicultural. Debido a la escasa información que se ... -
The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas-Another Model of Disrupted Human-Pathogen Co-Evolution
(MDPI, 2019)Epstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in ... -
The positive side of a negative reference: The delay between linguistic processing and common ground
(The Royal Society, 2017)Interlocutors converge on names to refer to entities. For example, a speaker might refer to a novel looking object as the jellyfish and, once identified, the listener will too. The hypothesized mechanism behind such ... -
The power of a control qubit in weak measurements
(NATURE PUBLISHING GROUP, 2017)In the late 80 s, a curious effect suggested by Aharanov et al. was found to lead to an anomalous amplification based on quantum measurements of weakly coupled systems. In this paper, we investigate the quantum control of ... -
The process of connectivity loss during habitat fragmentation and their consequences on population dynamics
(ELSEVIER SCIENCE BV, 2018)Understanding the processes and consequences of habitat fragmentation is highly relevant since it represents a serious threat to biodiversity. However, fragmentation includes several facets that are difficult to dissect, ...