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MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content
(Elsevier BV, 2017)
MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in ...
Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis
(COMPANY BIOLOGISTS LTD, 2018)
Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma ...
Fishing forward and reverse: Advances in zebrafish phenomics
(ELSEVIER, 2018)
Understanding how the genome instructs the phenotypic characteristics of an organism is one of the major scientific endeavors of our time. Advances in genetics have progressively deciphered the inheritance, identity and ...
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation
(NATURE PUBLISHING GROUP, 2019)
RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 ...
Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes
(MDPI, 2020-05)
The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ...
Homozygous mutation in CEP19, a gene mutated in morbid obesity, in Bardet-Biedl syndrome with predominant postaxial polydactyly
(BMJ PUBLISHING GROUP, 2018)
Background Bardet-Biedl syndrome (BBS) is a ciliopathy with extensive phenotypic variability and genetic heterogeneity. We aimed to discover the gene mutated in a consanguineous kindred with multiple cases of a BBS phenotype. ...
IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis
(Blackwell Munksgaard, 2019-10)
Background and Objective Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that are ...
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model
(OXFORD UNIV PRESS, 2018)
Amyotrophic lateral sclerosis (ALS) is a devastating adult-onset progressive neurodegenerative disease characterized by upper and lower motoneuron degeneration. A total of 20% of familial ALS (fALS) cases are explained by ...
The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis
(CELL PRESS, 2020)
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the ...
Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
(FRONTIERS MEDIA SA, 2018)
Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central ...