| dc.contributor | Elsevier | es_CL |
| dc.contributor.author | Sepulveda, D [Universidad de Chile] | es_CL |
| dc.contributor.author | Cortes, J. [Universidad de Chile] | es_CL |
| dc.contributor.author | Quest, Andrew F.G [Universidad de Chile] | es_CL |
| dc.contributor.author | Barrera,MJ [Universidad de Chile] | es_CL |
| dc.contributor.author | Bahamondes, V. [Universidad de Chile] | es_CL |
| dc.contributor.author | Aguilera, S [Clínica INDISA, Chile] | es_CL |
| dc.contributor.author | Urzúa, Ulises [Universidad de Chile] | es_CL |
| dc.contributor.author | Alliende,C. [Universidad de Chile] | es_CL |
| dc.contributor.author | Molina, C. [Chile. Universidad Mayor] | es_CL |
| dc.contributor.author | González, S. [Chile. Universidad Mayor] | es_CL |
| dc.contributor.author | Hermoso, M.A. [Universidad de Chile] | es_CL |
| dc.contributor.author | Leyton, C. [Universidad de Chile] | es_CL |
| dc.date.accessioned | 2018-09-07T13:04:09Z | |
| dc.date.available | 2018-09-07T13:04:09Z | |
| dc.date.issued | 2013 | es_CL |
| dc.identifier.citation | Castro, I., Sepulveda, D., Cortes, J., Quest, A. F. G., Barrera, M. J., Bahamondes, V., ... & Gonzalez, S. (2013). Oral dryness in Sjögren's syndrome patients. Not just a question of water. Autoimmunity reviews, 12(5), 567-574. | es_CL |
| dc.identifier.issn | ISSN 1568-9972 | es_CL |
| dc.identifier.issn | ESSN 1873-0183 | es_CL |
| dc.identifier.uri | https://ac.els-cdn.com/S1568997212002765/1-s2.0-S1568997212002765-main.pdf?_tid=3aa571fd-6b64-4072-be91-a61458ec1925&acdnat=1535147551_8b4af53a6952f2fa864875e06ea633eb | es_CL |
| dc.identifier.uri | https://doi.org/10.1016/j.autrev.2012.10.018 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/2609 | |
| dc.description.abstract | Sjögren's syndrome (SS) is a chronic autoimmune disease of undefined etiology. Patients with this syndrome suffer from severe alterations in both the quality and quantity of saliva and tears, due to impaired function of the relevant exocrine glands. Prevalent symptoms experienced by SS-patients include a persistent dry mouth sensation (xerostomia) and dry eyes (keratoconjunctivitis sicca). Water content of saliva depends of acetylcholine levels, glandular innervation, M3R signaling, calcium tunneling and water release, among other factors. However, unstimulated salivary flow correlates only poorly with symptoms of mouth dryness, raising the question as to which other components of saliva may be involved in mouth dryness experienced by SS-patients? Salivary mucins are glycoproteins characterized by the presence of large oligosaccharide side chains attached to the protein backbone. These molecules are key saliva components that are required to sequester water and thereby moisturize, as well as lubricate the oral mucosa. In the labial salivary glands of SS patients, morphological and functional alterations are detectable that affect the maturation and trafficking of salivary mucins. In this review, we will focus the discussion on these aspects of reduced salivary flow and decreased quality of salivary mucins, since they are likely to be responsible for xerostomia in SS-patients. | es_CL |
| dc.description.sponsorship | Este trabajo fue financiado por: Fondecyt-Chile #1120062, (MJG, SA, CM, SG), Fondecyt-Chile # 1090071 (AFGQ), CONICYT/Programa de Investigación Asociativa ACT 1111 (AFGQ). PhD fellowship Conicyt-Chile (MJB and JC), PhD fellowship BEP (DS). | es_CL |
| dc.format.extent | REVISIÓN | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | CIENCIAS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es_CL |
| dc.subject | INMUNOLOGÍA | es_CL |
| dc.title | Oral dryness in Sjogren's syndrome patients: Not just a question of water | es_CL |
| dc.type | Artículo o Paper | es_CL |
| umayor.indizador | COT | es_CL |
| umayor.politicas.sherpa/romeo | Licencia color: VERDE C/R (Se puede archivar el pre-print y el post-print o versión de editor/PDF, el autor no puede archivar la versión del editor/PDF)--Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares). Postcript: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares), Versión de editor/PDF: cross el autor no puede archivar la versión del editor/PDF, Condiciones generales: Authors pre-print on any website, including arXiv and RePEC, Author's post-print on author's personal website immediately, Author's post-print on open access repository after an embargo period of between 12, months and 48 months, Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months, Author's post-print may be used to update arXiv and RepEC, La versión de editor/PDF no puede utilizarse, Debe enlazar a la versión de editor con DOI, Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License// Disponible en: http://www.sherpa.ac.uk/romeo/issn/1568-9972/es/ | es_CL |
| umayor.indexado | WOS | es_CL |
| umayor.indexado | SCOPUS | es_CL |
| dc.identifier.doi | 10.1016/j.autrev.2012.10.018 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | sin información | es_CL |