| dc.contributor | BENTHAM SCIENCE PUBL LTD. | es_CL |
| dc.contributor.author | Anestopoulos, I. [Grecia. Democritus University of Thrace] | es_CL |
| dc.contributor.author | Voulgaridou, G. P. [Grecia. Democritus University of Thrace] | es_CL |
| dc.contributor.author | Franco, R. [Estados Unidos. University of Nebraska Lincoln] | es_CL |
| dc.contributor.author | Georgakilas, A. G. [Estados Unidos. University of North Carolina] | es_CL |
| dc.contributor.author | Ziech, D. [Chile. Universidad Mayor. Facultad de Medicina] | es_CL |
| dc.contributor.author | Malamou-Mitsi, V. [Grecia. University of Ioannina] | es_CL |
| dc.contributor.author | Pappa, A. [Grecia. Democritus University of Thrace] | es_CL |
| dc.contributor.author | Panayiotidis, M. I. [Grecia. University of Ioannina] | es_CL |
| dc.date.accessioned | 2018-09-07T13:04:11Z | |
| dc.date.available | 2018-09-07T13:04:11Z | |
| dc.date.issued | 2012 | es_CL |
| dc.identifier.citation | Hanafi, R., Anestopoulos, I., P Voulgaridou, G., Franco, R., G Georgakilas, A., Ziech, D., ... & I Panayiotidis, M. (2012). Oxidative stress based-biomarkers in oral carcinogenesis: how far have we gone?. Current molecular medicine, 12(6), 698-703. | es_CL |
| dc.identifier.issn | ISSN 1566-5240 | es_CL |
| dc.identifier.issn | ESSN 1875-5666 | es_CL |
| dc.identifier.uri | http://www.eurekaselect.com/99113/article | es_CL |
| dc.identifier.uri | https://doi.org/10.2174/156652412800792598 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/2622 | |
| dc.description.abstract | Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis. | es_CL |
| dc.description.sponsorship | Este trabajo fue financiado por: National Institutes of Health, Grant P20RR17675; Centers of Biomedical Research Excellence (COBRE); Layman Award from the University of Nebraska-Lincoln; Marie Curie International Reintegration Grant; 6th European Community Framework Program (MIRG-CT-2006-036585); Biology Department, ECU; postdoctoral fellowship, Hellenic Republic, Ministry of National Education and Religious Affairs; General Directorate of European & International Affairs; Directorate of International Relations in Education, Department of Scholarships; School of Community Health Sciences; Junior Faculty Research Award, University of Nevada-Reno, 7th European Community Framework Program (PIRG05-GA-2009-249315). | es_CL |
| dc.format.extent | ARTÍCULO ORIGINAL | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | CIENCIAS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es_CL |
| dc.subject | CIENCIAS DE LA SALUD | es_CL |
| dc.title | Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone? | es_CL |
| dc.type | Artículo o Paper | es_CL |
| umayor.indizador | COT | es_CL |
| umayor.politicas.sherpa/romeo | Licencia color: AMARILLO (Puede archivar el pre-print (ie la versión previa a la revisión por pares))--Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares) Post-print del autor: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares) siempre que se cumplan las restricciones: 12 meses de embargo Versión de editor/PDF: cross el autor no puede archivar la versión del editor/PDF. Condiciones generales: Author's pre-print on author's personal website, institutional repository and open access repository, Author's post-print on author's personal website, institutional repository, open access repository, PubMed Central and arXiv, No comercial, La fuente editorial debe reconocerse, Must link to journal homepage with DOI, La versión de editor/PDF no puede utilizarse// Disponible en: http://www.sherpa.ac.uk/romeo/issn/1566-5240/es/ | es_CL |
| umayor.indexado | WOS | es_CL |
| umayor.indexado | SCOPUS | es_CL |
| dc.identifier.doi | 10.2174/156652412800792598 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q3 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | sin información | es_CL |