Oxidative Stress Based-Biomarkers in Oral Carcinogenesis: How Far Have We Gone?
Fecha
2012Autor
Anestopoulos, I. [Grecia. Democritus University of Thrace]
Voulgaridou, G. P. [Grecia. Democritus University of Thrace]
Franco, R. [Estados Unidos. University of Nebraska Lincoln]
Georgakilas, A. G. [Estados Unidos. University of North Carolina]
Ziech, D. [Chile. Universidad Mayor. Facultad de Medicina]
Malamou-Mitsi, V. [Grecia. University of Ioannina]
Pappa, A. [Grecia. Democritus University of Thrace]
Panayiotidis, M. I. [Grecia. University of Ioannina]
Ubicación geográfica
Notas
HERRAMIENTAS
Resumen
Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
URI
http://www.eurekaselect.com/99113/articlehttps://doi.org/10.2174/156652412800792598
http://repositorio.umayor.cl/xmlui/handle/sibum/2622
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