Vista simple de metadatos

dc.contributorElsevieres_CL
dc.contributor.authorAnaya, Juan-Manuel [Colombia.Universidad del Rosario]es_CL
dc.contributor.authorAguilera, Sergio [Chile. Universidad Andrés Bello]es_CL
dc.contributor.authorÚrzua, Ulises [Universidad de Chile]es_CL
dc.contributor.authorMunroe, David [Estados Unidos. National Institutes of Health NIH]es_CL
dc.contributor.authorMolina, Claudio [Chile. Universidad Mayor]es_CL
dc.date.accessioned2018-09-07T14:11:38Z
dc.date.available2018-09-07T14:11:38Z
dc.date.issued2009es_CL
dc.identifier.citationPérez, P., Anaya, J. M., Aguilera, S., Urzúa, U., Munroe, D., Molina, C., ... & Ruiz-Narváez, E. (2009). Gene expression and chromosomal location for susceptibility to Sjögren's syndrome. Journal of autoimmunity, 33(2), 99-108.es_CL
dc.identifier.issnISSN 0896-8411es_CL
dc.identifier.urihttps://ac.els-cdn.com/S0896841109000699/1-s2.0-S0896841109000699-main.pdf?_tid=ee509e2c-4622-4b25-a498-710b20dadf45&acdnat=1535147367_08ee7f5c3961e0276535a63cfd9a56b6es_CL
dc.identifier.urihttps://doi.org/10.1016/j.jaut.2009.05.001es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/2693
dc.description.abstractPrimary Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease affecting mainly the exocrine glands. Its physio-pathology is poorly understood and most of the knowledge has been related to the inflammatory component. The aim of this work was to evaluate gene expression profiling in fractions enriched in epithelial cells from labial salivary glands (LSGs) of patients with primary SS and identify chromosomal regions harboring susceptibility genes expressed in epithelial cells. A combined approach of gene expression and genome-wide association study was used. Enriched epithelial cell fractions were obtained from LSGs of patients and controls. Amplified total RNA was labeled and hybridized to 10K cDNA microarrays. Results were normalized and subjected to statistical and functional analysis. A genome-wide microsatellite screen at 10 cM resolution (393 markers) was performed. In salivary gland-epithelial cells from patients 528 genes were expressed differentially in comparison to controls. Pathways not previously linked to disease were found to be altered. Twenty-eight and 15 genes associated with apoptosis were up-regulated and down regulated, respectively. Interferon-related genes, most of which participated in interferon signaling, were also found to be up-regulated. From the genome-wide screen, 6 markers showed evidence of highly significant association with the disease. Of these, five loci harbor genes differentially expressed in patients LSG-epithelial cells. Our results show that in enriched gland-epithelial cells of pSS, both pro-apoptotic/anti-apoptotic and interferon signaling inhibition/stimulation balances may occur. Genes found over-expressed in epithelial cells are candidates for disease susceptibility.es_CL
dc.description.sponsorshipEste trabajo fue financiado por: Fondecyt (1080006, 1050192, 1020755), Chile (MJG, SA, CM), MECESUP-Postgrado and Beca Conicyt (PP), Colciencias (2213-04-16715), Marshfield Foundation, and Rosario University (J-MA).es_CL
dc.format.extentARTÍCULO ORIGINALes_CL
dc.language.isoenes_CL
dc.publisherCIENCIASes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees_CL
dc.subjectINMUNOLOGÍAes_CL
dc.titleGene expression and chromosomal location for susceptibility to Sjogren's syndromees_CL
dc.typeArtículo o Paperes_CL
umayor.indizadorCOTes_CL
umayor.politicas.sherpa/romeoLicencia color: VERDE C/R (Se puede archivar el pre-print y el post-print o versión de editor/PDF, el autor no puede archivar la versión del editor/PDF)--Authors pre-print on any website, including arXiv and RePEC Author's post-print on author's personal website immediately Author's post-print on open access repository after an embargo period of between 12 months and 48 months Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months Author's post-print may be used to update arXiv and RepEC La versión de editor/PDF no puede utilizarse Debe enlazar a la versión de editor con DOI Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License// Disponible en: http://www.sherpa.ac.uk/romeo/issn/0896-8411/es/es_CL
umayor.indexadoWOSes_CL
dc.identifier.doi10.1016/j.jaut.2009.05.001es_CL]
umayor.indicadores.wos-(cuartil)Q1es_CL
umayor.indicadores.scopus-(scimago-sjr)sin informaciónes_CL


Vista simple de metadatos



Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
DSpace software copyright © 2002-2018  DuraSpace