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dc.contributorHindawi Publishing Corporationes_CL
dc.contributor.authorReyes, Eduardo [Chile.Universidad Diego Portales]es_CL
dc.contributor.authorOrellana, Nelson [Chile. Hospital de Carabineros]es_CL
dc.contributor.authorFuentealba, Cynthia [Chile. Hospital de Carabineros]es_CL
dc.date.accessioned2018-09-07T14:11:46Z
dc.date.available2018-09-07T14:11:46Z
dc.date.issued2013es_CL
dc.identifier.citationNigel P. Murray, Eduardo Reyes, Nelson Orellana, et al., “Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease,” The Scientific World Journal, vol. 2013, Article ID 762064, 7 pages, 2013. https://doi.org/10.1155/2013/762064.es_CL
dc.identifier.issnISSN 2356-6140es_CL
dc.identifier.issnESSN 1537-744Xes_CL
dc.identifier.urihttp://downloads.hindawi.com/journals/tswj/2013/762064.pdfes_CL
dc.identifier.urihttp://dx.doi.org/10.1155/2013/762064es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/2780
dc.description.abstractIntroduction. Although 90% of prostate cancer is considered to be localized, 20%-30% of patients will experience biochemical failure (BF), defined as serum PSA >0.2 ng/mL, after radical prostatectomy (RP). The presence of circulating prostate cells (CPCs) in men without evidence of BF may be useful to predict patients at risk for BF. We describe the frequency of CPCs detected after RP, relation with clinicopathological parameters, and association with biochemical failure. Methods and Patients. Serial blood samples were taken during followup after RP, mononuclear cells were obtained by differential gel centrifugation, and CPCs identified using standard immunocytochemistry using anti-PSA monoclonal antibodies. Age, pathological stage (organ confined, nonorgan confined), pathological grade, margin status (positive, negative), extracapsular extension, perineural, vascular, and lymphatic infiltration (positive, negative) were compared with the presence/absence of CPCs and with and without biochemical failure. Kaplan Meier methods were used to compare the unadjusted biochemical failure free survival of patients with and without CPCs. Results. 114 men participated, and secondary CPCs were detected more frequently in patients with positive margins, extracapsular extension, and vascular and lymphatic infiltration and were associated with biochemical failure independent of these clinicopathological variables, and with a shorter time to BF. Conclusions. Secondary CPCs are an independent risk factor associated with increased BF in men with a PSA <0.2 ng/mL after radical prostatectomy, but do not determine if the recurrence is due to local or systemic disease. These results warrant larger studies to confirm the findings.es_CL
dc.description.sponsorshipEste trabajo fue financiado por: Hospital de Carabineros de Chile.es_CL
dc.format.extentARTÍCULO ORIGINALes_CL
dc.language.isoenes_CL
dc.publisherCIENCIASes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees_CL
dc.subjectONCOLOGÍAes_CL
dc.titleSecondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Diseasees_CL
dc.typeArtículo o Paperes_CL
umayor.indizadorCOTes_CL
umayor.politicas.sherpa/romeoLicencia color: VERDE (Revista DOAJ. Se puede archivar el pre-print y el post-print o versión de editor/PDF)--DOAJ es una revista de acceso abierto Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares) Post-print del autor: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares) Versión de editor/PDF: green tick el autor puede archivar la versión del editor/PDF. Condiciones generales: La versión de editor/PDF puede utilizarse, Creative Commons Attribution License, Los autores afectados en el Reino Unido pueden depositar en OpenDepot// Disponible en: http://www.sherpa.ac.uk/romeo/issn/2356-6140/es/es_CL
umayor.indexadoWOSes_CL
umayor.indexadoSCOPUSes_CL
dc.identifier.doi10.1155/2013/762064es_CL]
umayor.indicadores.wos-(cuartil)Q2es_CL
umayor.indicadores.scopus-(scimago-sjr)sin informaciónes_CL


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