| dc.contributor | Elsevier | es_CL |
| dc.contributor.author | Bahamondes, V. [Universidad de Chile] | es_CL |
| dc.contributor.author | Sepúlveda, D. [Universidad de Chile] | es_CL |
| dc.contributor.author | Quest, A.F.G [Universidad de Chile] | es_CL |
| dc.contributor.author | Molina, C. [Chile. Universidad Mayor] | es_CL |
| dc.contributor.author | González, S. [Chile. Universidad Mayor] | es_CL |
| dc.date.accessioned | 2018-09-07T14:11:46Z | |
| dc.date.available | 2018-09-07T14:11:46Z | |
| dc.date.issued | 2013 | es_CL |
| dc.identifier.citation | Barrera, M. J., Bahamondes, V., Sepulveda, D., Quest, A. F. G., Castro, I., Cortés, J., ... & Ewert, P. (2013). Sjögren's syndrome and the epithelial target: a comprehensive review. Journal of autoimmunity, 42, 7-18. | es_CL |
| dc.identifier.issn | ISSN 0896-8411 | es_CL |
| dc.identifier.uri | https://ac.els-cdn.com/S0896841113000279/1-s2.0-S0896841113000279-main.pdf?_tid=2e227f3a-999f-484f-a795-b4bd7b6c8c26&acdnat=1535146952_993d0110d85c7cac11419820205f4a31 | es_CL |
| dc.identifier.uri | https://doi.org/10.1016/j.jaut.2013.02.001 | es_CL |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/2783 | |
| dc.description.abstract | The most difficult component in our understanding of human autoimmunity remains a rigorous dissection of etiological events. Indeed, the vast literature on autoimmune diseases focuses on the inflammatory response, with the hope of developing drugs that reduce inflammation. However, there is increasing recognition that understanding the immunobiology of target tissues will also have direct relevance to disease natural history, including breach of tolerance. Sjögren's syndrome is essentially an epitheliitis and there are major changes to normal architectural salivary organization. We propose that loss of homeostasis is the initial event that precipitates inflammation and that such inflammatory response includes not only the adaptive response, but also an intense innate immune/bystander response. To understand these events this review focuses on the architecture, phenotype, function and epithelial cell organization. We further submit that there are several critical issues that must be defined to fully understand epithelial cell immunobiology in Sjögren's syndrome, including defining epithelial cell polarity, cell-cell and cell to extracellular matrix interactions and a variety of chemical and mechanical signals. We also argue that disruption of tight junctions induces disorganization of the apical pole of salivary acinar cells in Sjögren's syndrome. In addition, there will be a critical role of inflammatory cytokines in the apico-basal relocation of tight junction proteins. Further, the altered disorganization and relocation of proteins that participate in secretory granule formation are also dysregulated in Sjögren's syndrome and will contribute to abnormalities of mucins within the extracellular matrix. Our ability to understand Sjögren's syndrome and develop viable therapeutic options will depend on defining these events of epithelial cell biology. | es_CL |
| dc.description.sponsorship | Este trabajo fue financiado por Fondecyt-Chile #1120062, (MJG, SA, CM, SG), Fondecyt-Chile # 1090071 (AFGQ), CONICYT/Programa de Investigación Asociativa ACT 1111 (AFGQ). PhD-fellowship Conicyt-Chile (MJB and JC), PhD-fellowship BEP (DS). | es_CL |
| dc.format.extent | REVISIÓN | es_CL |
| dc.language.iso | en | es_CL |
| dc.publisher | CIENCIAS | es_CL |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es_CL |
| dc.subject | INMUNOLOGÍA | es_CL |
| dc.title | Sjogren's syndrome and the epithelial target: A comprehensive review | es_CL |
| dc.type | Artículo o Paper | es_CL |
| umayor.indizador | COT | es_CL |
| umayor.politicas.sherpa/romeo | Licencia color: VERDE C/R (Se puede archivar el pre-print y el post-print o versión de editor/PDF, el autor no puede archivar la versión del editor/PDF)--Authors pre-print on any website, including arXiv and RePEC Author's post-print on author's personal website immediately Author's post-print on open access repository after an embargo period of between 12 months and 48 months Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months Author's post-print may be used to update arXiv and RepEC La versión de editor/PDF no puede utilizarse Debe enlazar a la versión de editor con DOI Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License// Disponible en: http://www.sherpa.ac.uk/romeo/issn/0896-8411/es/ | es_CL |
| umayor.indexado | WOS | es_CL |
| umayor.indexado | SCOPUS | es_CL |
| dc.identifier.doi | 10.1016/j.jaut.2013.02.001 | es_CL] |
| umayor.indicadores.wos-(cuartil) | Q1 | es_CL |
| umayor.indicadores.scopus-(scimago-sjr) | sin información | es_CL |