Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration
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2017-11Author
Catenaccio, Alejandra [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]
Díaz, Paula [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]
Lamont, Douglas J. [Reino Unido. University of Dundee. School of Life Sciences]
Wishart, Thomas M. [Reino Unido. University of Edinburgh. The Roslin Institute]
Hurtado, Maica Llavero [Reino Unido. University of Edinburgh. The Roslin Institute]
Court, Felipe A. [Chile. Universidad Mayor. Facultad de Ciencias. Centro de Biología Integrativa]
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Abstract
Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for our undertstanding of the complex non-cell autonomous role of glial cells in the regulation of axonal degeneration. To shed light on the complexity of the molecular machinery governing axonal degeneration we employ a multi-model, unbiased, in vivo approach combining morphological assesment and quantitative proteomics with in silico-based higher order functional clustering to genetically uncouple the intrinsic and extrinsic processes governing Wallerian degeneration. Highlighting a pivotal role for glial cells in the early stages fragmenting the axon by a cytokinesis-like process and a cell autonomous stage of axonal disintegration associated to mitochondrial dysfunction
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http://repositorio.umayor.cl/xmlui/handle/sibum/436https://doi.org/10.1038/cddis.2017.489
https://www.nature.com/articles/cddis2017489.pdf
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