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dc.contributor.authorVidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]es_CL
dc.contributor.authorMuñoz-Llanos, Mauricioes_CL
dc.contributor.authorGarcía-Pérez, María A.es_CL
dc.contributor.authorXu, Xiaojianges_CL
dc.contributor.authorTejos-Bravo, Macarenaes_CL
dc.contributor.authorMoyano, Tomás C.es_CL
dc.contributor.authorGutiérrez, Rodrigo A.es_CL
dc.contributor.authorAguayo, Felipe I.es_CL
dc.contributor.authorPacheco, Anibales_CL
dc.contributor.authorGarcía-Rojo, Gonzaloes_CL
dc.contributor.authorAliaga, Estebanes_CL
dc.contributor.authorRojas, Paulina S.es_CL
dc.contributor.authorCidlowski, John A.es_CL
dc.contributor.authorFiedler, Jenny L.es_CL
dc.date.accessioned2020-04-08T14:11:55Z
dc.date.accessioned2020-04-13T18:12:41Z
dc.date.available2020-04-08T14:11:55Z
dc.date.available2020-04-13T18:12:41Z
dc.date.issued2018es_CL
dc.identifier.citationMuñoz-Llanos, M., García-Pérez, M. A., Xu, X., Tejos-Bravo, M., Vidal, E. A., Moyano, T. C., ... & Aliaga, E. (2018). MicroRNA profiling and bioinformatics target analysis in dorsal hippocampus of chronically stressed rats: relevance to depression pathophysiology. Frontiers in molecular neuroscience, 11, 251.es_CL
dc.identifier.issn1662-5099es_CL
dc.identifier.urihttps://doi.org/10.3389/fnmol.2018.00251es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/6169
dc.description.abstractStudies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including mood disorders. The studies in rodents have revealed that chronic exposure to stress negatively affects synaptic plasticity by triggering changes in the production of trophic factors, subunit levels of glutamate ionotropic receptors, neuron morphology, and neurogenesis in the adult hippocampus. These modifications may account for the impairment in learning and memory processes observed in chronically stressed animals. It is plausible then, that stress modifies the interplay between signal transduction cascades and gene expression regulation in the hippocampus, therefore leading to altered neuroplasticity and functioning of neural circuits. Considering that miRNAs play an important role in post-transcriptional-regulation of gene expression and participate in several hippocampus-dependent functions; we evaluated the consequences of chronic stress on the expression of miRNAs in dorsal (anterior) portion of the hippocampus, which participates in memory formation in rodents. Here, we show that male rats exposed to daily restraint stress (2.5 h/day) during 7 and 14 days display a differential profile of miRNA levels in dorsal hippocampus and remarkably, we found that some of these miRNAs belong to the miR-379-410 cluster. We confirmed a rise in miR-92a and miR-485 levels after 14 days of stress by qPCR, an effect that was not mimicked by chronic administration of corticosterone (14 days). Our in silico study identified the top-10 biological functions influenced by miR-92a, nine of which were shared with miR-485: Nervous system development and function, Tissue development, Behavior, Embryonic development, Organ development, Organismal development, Organismal survival, Tissue morphology, and Organ morphology. Furthermore, our in silico study provided a landscape of potential miRNA-92a and miR-485 targets, along with relevant canonical pathways related to axonal guidance signaling and cAMP signaling, which may influence the functioning of several neuroplastic substrates in dorsal hippocampus. Additionally, the combined effect of miR-92a and miR-485 on transcription factors, along with histone-modifying enzymes, may have a functional relevance by producing changes in gene regulatory networks that modify the neuroplastic capacity of the adult dorsal hippocampus under stress.es_CL
dc.description.sponsorshipFONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [1120528]; Fondo Central de Investigacion, Universidad de Chile [ENL025/16, ES090079]; Instituto Milenio iBio - Iniciativa Cientifica Milenio MINECONes_CL
dc.description.sponsorshipThis study was supported by the following grants: FONDECYT 1120528 (JLF), Fondo Central de Investigacion, Universidad de Chile ENL025/16 (JLF), ES090079 (JAC). Research in RG and EV laboratories is funded by Instituto Milenio iBio - Iniciativa Cientifica Milenio MINECON.es_CL
dc.language.isoenes_CL
dc.publisherFRONTIERS MEDIA SAes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceFront. Molec. Neurosci., AGO 2018. 11
dc.subjectNeuroscienceses_CL
dc.titleMicroRNA Profiling and Bioinformatics Target Analysis in Dorsal Hippocampus of Chronically Stressed Rats: Relevance to Depression Pathophysiologyes_CL
dc.typeArtículoes_CL
umayor.facultadCIENCIASes_CL
umayor.politicas.sherpa/romeoDOAJ Gold, Green Publishedes_CL
umayor.indexadoWOS:000440817700001es_CL
umayor.indexadoPMID: 30127715es_CL
dc.identifier.doiDOI: 10.3389/fnmol.2018.00251es_CL]
umayor.indicadores.wos-(cuartil)Q2es_CL
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 46 Hes_CL


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