• Login
    View Item 
    •   DSpace Home
    • INVESTIGACIÓN
    • Artículos WOS
    • View Item
    •   DSpace Home
    • INVESTIGACIÓN
    • Artículos WOS
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    El Repositorio Institucional de la Universidad Mayor, tiene como objetivo publicar, en formato digital, todos los objetos derivados de su producción científica, académica, cultural y artística. En palabras simples es una vitrina que pone en valor su patrimonio documental.


    InformaciónInicioAcerca deFormulariosManualesAcervo

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    xmlui.EPerson.Navigation.loginxmlui.EPerson.Navigation.register

    Generation of a protocol for the synthesis of chitosan nanoparticles loaded with florfenicol through the ionic gelation method

    Thumbnail
    Date
    2018
    Author

    Parodi, Jorge [Univ Mayor, Fac Ciencias Vicerrectoria Invest & Postgrad, Lab Biol Celular & Mol Aplicada, Temuco, Chile]

    Carmona, Erico R.

    Plaza, Tania

    Recio-Sánchez, Gonzalo

    Geographic location

    Note
    Tools
    Cite
    Vea como citar este artículo

    Show full item record
    Abstract
    The formation of nanoparticles of chitosan by the ionic gelation method has a high potential for loading, transport and controlled release of molecules. It is a simple method and the nanoparticles have good absorption, stability, biocompatibility and low toxicity. Florfenicol is one of the most used antibiotics in the aquaculture industry and is administered mixed with the feed in high concentrations, which generates problems of effective doses and unwanted residues. In this way, the synthesis of chitosan (Q) nanoparticles loaded with florfenicol could provide advantages when it comes to protecting, transporting and releasing the drug in fish of economic interest in a controlled manner. In the present study, nanoparticles of chitosan and sodium tripolyphosphate (TPP) with and without florfenicol were synthesized to evaluate their effective loading and release. The results obtained with FTIR spectrometry corroborate the formation of the Q-TPP nanoparticles with the changes observed in the infrared spectra patterns between the matrix chitosan and the synthesized nanoparticles. Q-TPP nanoparticles can carry between 48 and 50% of florfenicol inside. The in vitro release assay of the antibiotic showed a controlled and stable release over time under conditions of acid pH and controlled temperature of 15 degrees C for up to 10 days. Finally, it is shown that the Q-TPP nanoparticles have the potential to trap and release the evaluated drug in a controlled manner.
    URI
    https://doi.org/10.15381/rivep.v29i4.15203
    http://repositorio.umayor.cl/xmlui/handle/sibum/6244
    Collections
    • Artículos WOS

    Si usted es autor(a) de este documento y NO desea que su publicación tenga acceso público en este repositorio, por favor complete el formulario aquí.


    Contact Us | Send Feedback
    Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
    DSpace software copyright © 2002-2018  DuraSpace
     

     



    Contact Us | Send Feedback
    Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
    DSpace software copyright © 2002-2018  DuraSpace