Draft genomes and reference transcriptomes extend the coding potential of the fish pathogen Piscirickettsia salmonis
Fecha
2018Autor
Valdés, Jorge H. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]
Millar, Angela D.
Tapia, Paz
Gómez, Fernando A.
Marshall, Sergio H.
Fuentes, Derie E.
Ubicación geográfica
Notas
HERRAMIENTAS
Resumen
Background: Draft and complete genome sequences from bacteria are key tools to understand genetic determinants involved in pathogenesis in several disease models. Piscirickettsia salmonis is a Gram-negative bacterium responsible for the Salmon Rickettsial Syndrome (SRS), a bacterial disease that threatens the sustainability of the Chilean salmon industry. In previous reports, complete and draft genome sequences have been generated and annotated. However, the lack of transcriptome data underestimates the genetic potential, does not provide information about transcriptional units and contributes to disseminate annotation errors. Results: Here we present the draft genome and transcriptome sequences of four P. salmonis strains. We have identified the transcriptional architecture of previously characterized virulence factors and trait-specific genes associated to cation uptake, metal efflux, antibiotic resistance, secretion systems and other virulence factors. Conclusions: This data has provided a refined genome annotation and also new insights on the transcriptional structures and coding potential of this fish pathogen. (C) Pontificia Universidad Catolica de Valparaiso. Production and hosting by Elsevier B.V. All rights reserved.
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