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dc.contributor.authorCourt, F. A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile]es_CL
dc.contributor.authorEscudero, C. A.es_CL
dc.contributor.authorCabeza, C.es_CL
dc.contributor.authorMoya-Alvarado, G.es_CL
dc.contributor.authorMaloney, M. T.es_CL
dc.contributor.authorFlores, C. M.es_CL
dc.contributor.authorWu, C.es_CL
dc.contributor.authorMobley, W. C.es_CL
dc.contributor.authorBronfman, F. C.es_CL
dc.date.accessioned2020-04-12T14:11:55Z
dc.date.accessioned2020-04-14T15:37:36Z
dc.date.available2020-04-12T14:11:55Z
dc.date.available2020-04-14T15:37:36Z
dc.date.issued2019es_CL
dc.identifier.citationEscudero, C. A., Cabeza, C., Moya-Alvarado, G., Maloney, M. T., Flores, C. M., Wu, C., ... & Bronfman, F. C. (2019). c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling. Scientific reports, 9(1), 1-17.es_CL
dc.identifier.issn2045-2322es_CL
dc.identifier.urihttps://doi.org/10.1038/s41598-019-42420-6es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/6367
dc.description.abstractDuring the development of the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate survival and connectivity. During this process, nerve growth factor (NGF)-TrkA signaling in axons communicates NGF-mediated trophic responses in signaling endosomes. Whether axonal p75 signaling contributes to neuronal death and how signaling endosomes contribute to p75 signaling has not been established. Using compartmentalized sympathetic neuronal cultures (CSCGs) as a model, we observed that the addition of BDNF to axons increased the transport of p75 and induced death of sympathetic neurons in a dynein-dependent manner. In cell bodies, internalization of p75 required the activity of JNK, a downstream kinase mediating p75 death signaling in neurons. Additionally, the activity of Rab5, the key GTPase regulating early endosomes, was required for p75 death signaling. In axons, JNK and Rab5 were required for retrograde transport and death signaling mediated by axonal BDNF-p75 in CSCGs. JNK was also required for the proper axonal transport of p75-positive endosomes. Thus, our findings provide evidence that the activation of JNK by p75 in cell bodies and axons is required for internalization to a Rab5-positive signaling endosome and the further propagation of p75-dependent neuronal death signals.es_CL
dc.description.sponsorshipFondecytComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [1171137, 1150766, 310076]; Basal Center of Excellence in Science and Technology CONICYT PIA/BASAL [PFB 12]; Millennium-Nucleus [P07/011-F]; Geroscience Center for Brain and Metabolism [FONDAP-15150012]; CONICYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT); US National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P01NS092525, R01AG055523]es_CL
dc.description.sponsorshipThe authors gratefully acknowledge the financial support from Fondecyt 1171137 (FB), the Basal Center of Excellence in Science and Technology CONICYT PIA/BASAL PFB 12 (FB), Millennium-Nucleus-P07/011-F (FB and FC), the Geroscience Center for Brain and Metabolism (FONDAP-15150012) (FC), Fondecyt 1150766 (FC), the PhD scholar fellowship from CONICYT (CE, CC, and GMA), and FONDECYT 310076 (CF); US National Institutes of Health P01NS092525 and R01AG055523 (WM).es_CL
dc.language.isoenes_CL
dc.publisherNATURE PUBLISHING GROUPes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceSci Rep, ABR, 2019. 9
dc.subjectMultidisciplinary Scienceses_CL
dc.titlec-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signalinges_CL
umayor.facultadCIENCIAS
umayor.politicas.sherpa/romeoDOAJ Gold, Green Publishedes_CL
umayor.indexadoWOS:000464495700018es_CL
umayor.indexadoPMID: 30988348es_CL
dc.identifier.doiDOI: 10.1038/s41598-019-42420-6es_CL]
umayor.indicadores.wos-(cuartil)Q4es_CL
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 34 Hes_CL


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