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dc.contributor.authorBurgos, Héctor [Univ Mayor, Fac Ciencias, Nucleo Disciplinar Psicol, Santiago, Chile]es_CL
dc.contributor.authorBarra, Rafaeles_CL
dc.contributor.authorMorgan, Carloses_CL
dc.contributor.authorSaez-Briones, Patricioes_CL
dc.contributor.authorReyes-Parada, Migueles_CL
dc.contributor.authorMorales, Bernardoes_CL
dc.contributor.authorHernández, Alejandroes_CL
dc.date.accessioned2020-04-12T14:11:55Z
dc.date.accessioned2020-04-14T15:37:43Z
dc.date.available2020-04-12T14:11:55Z
dc.date.available2020-04-14T15:37:43Z
dc.date.issued2019es_CL
dc.identifier.citationBarra, R., Morgan, C., Sáez-Briones, P., Reyes-Parada, M., Burgos, H., Morales, B., & Hernández, A. (2019). Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition. Nutrition reviews, 77(2), 65-80.es_CL
dc.identifier.issn0029-6643es_CL
dc.identifier.issn1753-4887es_CL
dc.identifier.urihttps://doi.org/10.1093/nutrit/nuy047es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/6439
dc.description.abstractStudies in rats have shown that a decrease in either protein content or total dietary calories results in molecular, structural, and functional changes in the cerebral cortex and hippocampus, among other brain regions, which lead to behavioral disturbances, including learning and memory deficits. The neurobiological bases underlying those effects depend at least in part on fetal programming of the developing brain, which in turn relies on epigenetic regulation of specific genes via stable and heritable modifications of chromatin. Prenatal malnutrition also leads to epigenetic programming of obesity, and obesity on its own can lead to poor cognitive performance in humans and experimental animals, complicating understanding of the factors involved in the fetal programming of neuroplasticity deficits. This review focuses on the role of epigenetic mechanisms involved in prenatal malnutrition-induced brain disturbances, which are apparent at a later postnatal age, through either a direct effect of fetal programming on brain plasticity or an indirect effect on the brain mediated by the postnatal development of obesity.es_CL
dc.description.sponsorshipFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [3130573]; FONDECYTComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT [1161524]; DICYT from Direccion de Investigacion Cientifica y Tecnologica of Universidad de Santiago de Chile [021501RP, 021643HK]es_CL
dc.description.sponsorshipThis work was supported by postdoctoral grant 3130573 from Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) given to R.B., grant 1161524 from FONDECYT given to BM, and DICYT grants 021501RP and 021643HK from Direccion de Investigacion Cientifica y Tecnologica of Universidad de Santiago de Chile.es_CL
dc.language.isoenes_CL
dc.publisherOXFORD UNIV PRESS INCes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.sourceNutr. Rev., FEB, 2019. 77(2): p. 65-80
dc.subjectNutrition & Dieteticses_CL
dc.titleFacts and hypotheses about the programming of neuroplastic deficits by prenatal malnutritiones_CL
dc.typeRevisiónes_CL
umayor.facultadCIENCIAS
umayor.politicas.sherpa/romeoRoMEO green journal (Se puede archivar el pre-print y el post-print o versión de editor/PDF). Disponible en: http://sherpa.ac.uk/romeo/index.phpes_CL
umayor.indexadoWOS:000456024100001es_CL
umayor.indexadoPMID: 30445479es_CL
dc.identifier.doiDOI: 10.1093/nutrit/nuy047es_CL]
umayor.indicadores.wos-(cuartil)Q1es_CL
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 131 Hes_CL


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