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    Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition

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    Date
    2019
    Author

    Burgos, Héctor [Univ Mayor, Fac Ciencias, Nucleo Disciplinar Psicol, Santiago, Chile]

    Barra, Rafael

    Morgan, Carlos

    Saez-Briones, Patricio

    Reyes-Parada, Miguel

    Morales, Bernardo

    Hernández, Alejandro

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    Abstract
    Studies in rats have shown that a decrease in either protein content or total dietary calories results in molecular, structural, and functional changes in the cerebral cortex and hippocampus, among other brain regions, which lead to behavioral disturbances, including learning and memory deficits. The neurobiological bases underlying those effects depend at least in part on fetal programming of the developing brain, which in turn relies on epigenetic regulation of specific genes via stable and heritable modifications of chromatin. Prenatal malnutrition also leads to epigenetic programming of obesity, and obesity on its own can lead to poor cognitive performance in humans and experimental animals, complicating understanding of the factors involved in the fetal programming of neuroplasticity deficits. This review focuses on the role of epigenetic mechanisms involved in prenatal malnutrition-induced brain disturbances, which are apparent at a later postnatal age, through either a direct effect of fetal programming on brain plasticity or an indirect effect on the brain mediated by the postnatal development of obesity.
    URI
    https://doi.org/10.1093/nutrit/nuy047
    http://repositorio.umayor.cl/xmlui/handle/sibum/6439
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    Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
    DSpace software copyright © 2002-2018  DuraSpace