• Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (Octodon degus) 

      Oliva, Carolina A.; Rivera, Daniela S. [Univ Mayor, Fac Ciencias, GEMA Ctr Genom, Ecol & Environm, Chile]; Torres, Angie K.; Lindsay, Carolina B.; Tapia-Rojas, Cheril; Bozinovic, Francisco; Inestrosa, Nibaldo C. (MDPI, 2023-01)
      In Octodon degus, the aging process is not equivalent between sexes and worsens for females. To determine the beginning of detrimental features in females and the ways in which to improve them, we compared adult females ...
    • Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes 

      Cordero, Esteban M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortes, Bastian I. [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Palominos, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Parra, Pedro [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Mella, Tania [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henrríquez, Constanza [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Salazar, Nelda [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Monasterio, Gustavo; Cafferata, Emilio A.; Murgas, Paola [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (MDPI, 2020-05)
      The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ...
    • Aging Hallmarks and the Role of Oxidative Stress 

      Maldonado, Edio; Morales-Pison, Sebastián [Univ Mayor, Fac Med & Ciencias Salud, Ctr Oncol Precis COP, Chile]; Urbina, Fabiola; Solari, Aldo (MDPI, 2023-03)
      Aging is a complex biological process accompanied by a progressive decline in the physical function of the organism and an increased risk of age-related chronic diseases such as cardiovascular diseases, cancer, and ...
    • Alcohol and marijuana use as daily predictors of suicide ideation and attempts among adolescents prior to psychiatric hospitalization 

      Iriarte, Antonia Díaz-Valdés [Univ Mayor, Fac Humanidades, Soc & Hlth Res Ctr]; Sellers, Christina M.; Battalen, Adeline Wyman; O'Brien, Kimberly H. McManama (ELSEVIER IRELAND LTD, 2019)
      Objective: Little research has been conducted on alcohol use, marijuana use, and suicide ideation and attempts on a daily level, and specifically among adolescents prior to inpatient hospitalization. The purpose of this ...
    • Alcohol Consumption in Later Life and Mortality in the United States: Results from 9 Waves of the Health and Retirement Study 

      Calvo, Esteban [Univ Mayor, Fac Humanidades, Soc & Hlth Res Ctr, Santiago, Chile]; Keyes, Katherine M.; Ornstein, Katherine A.; Rutherford, Caroline; Fox, Matthew P.; Staudinger, Ursula M.; Fried, Linda P. (WILEY, 2019)
      Background Alcohol consumption in later life has increased in the past decade, and the relationship between alcohol consumption and mortality is controversial. Recent studies suggest little, if any, health benefit to ...
    • Alimentary necrobacillosis in alpacas 

      Flores, Carlos [Univ Mayor, Santiago, Chile]; Carvallo, Francisco R.; Uzal, Francisco A.; Diab, Santiago S.; Giannitti, Federico; Crossley, Beate; Wuenschmann, Arno (SAGE PUBLICATIONS INC, 2020)
      Ulcers of the oral cavity, esophagus, and gastric compartments of South American camelids are uncommon. Multifocal-to-coalescing ulcers were identified in the oral cavity, esophagus, and/or gastric compartments of 5 alpacas ...
    • ALS-linked protein disulfide isomerase variants cause motor dysfunction 

      Colombo, Alicia [Universidad de Chile]; Saaranen, Mirva J. [Finlandia. University of Oulu. Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine]; Pérez, Viviana [Chile. Universidad de Concepción]; Ojeda, Jorge [Chile. Universidad de Concepción]; Bustos, Fernando J. [Chile. Universidad Andrés Bello] (CIENCIAS, 2016)
      Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
    • Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice 

      Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile]; Martínez, Nicolás W. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago, Chile]; Kline, Rachel A.; Dissanayake, Kosala N.; Hurtado, Maica Llavero; Ahl, Alexander; Mole, Alannah J.; Lamont, Douglas J.; Ribchester, Richard R.; Wishart, Thomas M.; Murray, Lyndsay M. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019)
      Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic degeneration are early and critical elements of nearly all human ...
    • Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury 

      Richards, Natalie [Wolfson Centre for Age-Related Diseases, Kings College London, London,United Kingdom]; Schmid, Annina B. [University of Oxford, Oxford. Nuffield Department of Clinical Neurosciences]; Barroso, Alejandro [Reino Unido. Wolfson Centre for Age-Related Diseases]; Zhu, Lan [Reino Unido. Wolfson Centre for Age-Related Diseases]; Ivulic, Dinka [Pontificia Universidad Católica de Chile]; Zhu, Ning [Reino Unido. University of Oxford. Nuffield Department of Clinical Neurosciences]; Anwandter, Philipp [Pontificia Universidad Católica de Chile]; Manzoor, Bhat A. [Estados Unidos. UT Health Science Center at San Antonio] (CIENCIAS, 2016)
      Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of ...
    • Alumoxane Film For Corrosion Protection Of 2024 Aluminum Alloy 

      Vejar, Nelson D.; Rojas, Javier; Alvarado, Claudia (2023)
    • Amazonian trees show increased edge effects due to Atlantic Ocean warming and northward displacement of the Intertropical Convergence Zone since 1980 

      Venegas-González, Alejandro [Univ Mayor, Escuela Ingn Forestal, Hemera Ctr Observac Tierra, Fac Ciencias]; Roig, Fidel Alejandro [Univ Mayor, Escuela Ingn Forestal, Hemera Ctr Observac Tierra, Fac Ciencias, Santiago 8340589, Chile]; Albiero-Junior, Alci; Campana Camargo, JoséLuis; Schongart, Jochen; Pinto, Renan Mercuri; Tomazello-Filho, Mario (ELSEVIER, 2019)
      Recent investigations indicate a warming of Atlantic Ocean surface waters since 1980, probably influenced by anthropic actions, inducing rainfall intensification mainly during the rainy season and slight reductions during ...
    • Ambient Temperature and Stroke Risk: Evidence Supporting a Short-Term Effect at a Population Level From Acute Environmental Exposures 

      Hoffmeister, L. [Univ Mayor, Escuela Salud Publ, Santiago, Chile]; Lavados, P. M.; Moraga, A. M.; Vejar, A.; Gajardo, C.; San Martin, D.; Portales, B.; Muñoz-Venturelli, P.; Almeida, M.; Olavarria, V. (LIPPINCOTT WILLIAMS & WILKINS, 2018)
    • An Action Framework For The Participatory Assessment Of Nature Based Solutions In Cities 

      Van Der Jagt, Alexander P. N.; Buijs, Arjen; Van Lierop, Martina; Pauleit, Stephan; Randrup, Thomas B.; Wild, Tom; Dobbs, Cynnamon [Univ Mayor, Ctr Modeling & Monitoring Ecosyst, Sch Forestry, Chile] (2023)
    • An efficient semi-analytical method to compute displacements and stresses in an elastic half-space with a hemispherical pit 

      Boccardo, Valeria [Chile. Universidad Mayor. Escuela de Ingeniería]; Durán, Mario [Pontificia Universidad Católica de Chile]; Godoy, Eduardo [Chile. Ingenieros Matemat Consultores Asociados, INGMA] (CIENCIAS, 2015)
      This paper presents an efficient method to calculate the displacement and stress fields in an isotropic elastic half-space having a hemispherical pit and being subject to gravity. The method is semi-analytical and takes ...
    • An Eight-Year Survey for Canine Distemper Virus Indicates Lack of Exposure in the Endangered Darwin's Fox (Lycalopex fulvipes) 

      Hidalgo-Hermoso, Ezequiel; Cabello, Javier; Vega, Consuelo; Kroeger-Gómez, Hedy [Univ Mayor, Escuela Med Vet, Chile]; Moreira-Arce, Dario; Napolitano, Constanza; Navarro, Carlos; Sacristan, Irene; Cevidanes, Aitor; Di Cataldo, Sophia; Dubovi, Edward J.; Mathieu-Benson, Christian; Millan, Javier (Wildlife Disease Association, Inc., 2020-04)
      No evidence of exposure to canine distemper virus (CDV) was detected in 70 samples corresponding to 58 wild-trapped Darwin's foxes (Lycalopex fulvipes) in Chile. Given its current endangered status and it being immunologically ...
    • An Empirical Study of Exhaustive Matching for Improving Motion Field Estimation 

      Lazcano, Vanel [Univ Mayor, Fac Estudios Interdisciplinarios, Nucleo Matemat Fis & Estadist, Santiago 7500628, Chile] (MDPI, 2018)
      Optical flow is defined as the motion field of pixels between two consecutive images. Traditionally, in order to estimate pixel motion field (or optical flow), an energy model is proposed. This energy model is composed of ...
    • An Overview, of Injectable Thermo-Responsive Hydrogens and Advances in their Biomedical Applications 

      Avila-Salas, Fabián [Univ Mayor, Fac Ciencias, Ctr Nanotecnol Aplicada, Chile]; Durán-Lara, Esteban F. (Bentham Science, 2020)
      Background: Injectable hydrogels are a thermo-responsive system based on biomaterials. Injectable hydrogels have been broadly investigated mainly as vehicles or scaffolds of therapeutic agents that include drugs, proteins, ...
    • An unusual presentation of disseminated histoplasmosis in a non-HIV patient from Vietnam 

      Silva, Víctor [Univ Mayor, Fac Sci, Sch Med Technol, Santiago, Chile]; Tran Cam Van; Nguyen, Sau V.; Nguyen, Thuong V.; Hoang, Ha Thi T.; Phuong Thi Minh Pham; Do, Hien Thi T.; Vu, Ha T.; Dao, Ghi. H.; Nguyen, Long H.; Cantarelli, Vlademir Vicente (ASOCIACION ESPANOLA MICOLOGIA-AEM, 2019)
      Background: Histoplasmosis is a systemic infection caused by the dimorphic fungus Histoplasma capsulaturn, naturally found in nitrogen-rich soil, whose main transmission route is the inhalation of conidia. Up to 95% of ...


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