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Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
(FRONTIERS MEDIA SA, 2018)
Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central ...
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
(FRONTIERS MEDIA SA, 2018)
Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several age-dependent neurodegenerative diseases and may be a major contributing factor in ...
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
(NATURE PUBLISHING GROUP, 2018)
Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
(NATL ACAD SCIENCES, 2018)
Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...
Unraveling the role of motoneuron autophagy in ALS
(TAYLOR & FRANCIS INC, 2018)
In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. Genetic evidence indicates that mutations in autophagy-regulatory ...