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Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
(NATL ACAD SCIENCES, 2018)
Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ...
Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits
(PUBLIC LIBRARY SCIENCE, 2019)
Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in ...
Unraveling the role of motoneuron autophagy in ALS
(TAYLOR & FRANCIS INC, 2018)
In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. Genetic evidence indicates that mutations in autophagy-regulatory ...
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)
BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ...
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells
(TAYLOR & FRANCIS INC, 2019)
The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent AMPK-dependent macroautophagic/autophagic flux, which is not ...
Dinámica competitiva de las universidades en chile y la necesidad de potenciar el mercado de la educación a distancia
(, 2015)
Los mercados de educación superior se caracterizan por ser altamente competitivos. En este escenario un grupo de universidades han definido su estrategia de crecimiento a través de la oferta de programas de estudios en el ...
Imogolite in water: Simulating the effects of nanotube curvature on structure and dynamics
(Elsevier BV, 2019-07)
Imogolite is a fascinating inorganic nanotube that is found in nature or synthesized in a laboratory. The synthesis process is carried out in liquid media, and leads to the formation of almost monodisperse diameter nanotubes. ...