| dc.contributor | Blackwell Munksgaard | es |
| dc.contributor.author | Cafferata, Emilio A. | |
| dc.contributor.author | Terraza-Aguirre, Claudia | |
| dc.contributor.author | Barrera, Romina | |
| dc.contributor.author | Faúndez, Nicolás | |
| dc.contributor.author | González, Nicolás | |
| dc.contributor.author | Rojas, Carolina | |
| dc.contributor.author | Melgar-Rodríguez, Samanta | |
| dc.contributor.author | Hernández, Marcela | |
| dc.contributor.author | Carvajal, Paola | |
| dc.contributor.author | Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] | |
| dc.contributor.author | González, Fermin E. | |
| dc.contributor.author | Covarrubias, Cristian | |
| dc.contributor.author | Vernal, Rolando | |
| dc.date.accessioned | 2020-12-18T19:41:24Z | |
| dc.date.available | 2020-12-18T19:41:24Z | |
| dc.date.issued | 2020-04 | |
| dc.identifier.citation | Cafferata, E. A., Terraza‐Aguirre, C., Barrera, R., Faúndez, N., González, N., Rojas, C., ... & González, F. E. (2020). Interleukin‐35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis. Journal of Clinical Periodontology, 47(6), 676-688. | es |
| dc.identifier.issn | 0303-6979 | |
| dc.identifier.issn | 1600-051X | |
| dc.identifier.other | ID de PubMed: 32160331 | |
| dc.identifier.other | Número WOS: WOS:000523200200001 | |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/7273 | |
| dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/jcpe.13282 | |
| dc.identifier.uri | https://doi.org/10.1111/jcpe.13282 | |
| dc.identifier.uri | https://cgb.umayor.cl/publicaciones/interleukin-35-inhibits-alveolar-bone-resorption-by-modulating-the-th17-treg-imbalance-during-periodontitis | |
| dc.description.abstract | Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting alveolar bone resorption. Interleukin (IL)-35 is a novel anti-inflammatory cytokine with therapeutic properties in diseases whose pathogenesis is associated with the Th17/Treg imbalance; however, its role during periodontitis has not been established yet. This study aimed to elucidate whether IL-35 inhibits the alveolar bone resorption during periodontitis by modulating the Th17/Treg imbalance. Materials and Methods Mice with ligature-induced periodontitis were treated with locally or systemically administrated IL-35. As controls, periodontitis-affected mice without IL-35 treatment and non-ligated mice were used. Alveolar bone resorption was measured by micro-computed tomography and scanning electron microscopy. The Th17/Treg pattern of the immune response was analysed by qPCR, ELISA, and flow cytometry. Results IL-35 inhibited alveolar bone resorption in periodontitis mice. Besides, IL-35 induced less detection of Th17 lymphocytes and production of Th17-related cytokines, together with higher detection of Treg lymphocytes and production of Treg-related cytokines in periodontitis-affected tissues. Conclusion IL-35 is beneficial in the regulation of periodontitis; particularly, IL-35 inhibited alveolar bone resorption and this inhibition was closely associated with modulation of the periodontal Th17/Treg imbalance. | es |
| dc.description.sponsorship | This study was financially supported by FONDECYT grant 1181780 from the Chilean Governmental, Agencia Nacional de Investigacion y Desarrollo (ANID). EAC was a recipient of a PhD Scholarship from the Graduate School of the Faculty of Dentistry, Universidad de Chile. | es |
| dc.format.extent | 13 p., PDF | es |
| dc.language.iso | en | es |
| dc.publisher | Blackwell Munksgaard | es |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es |
| dc.title | Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis | es |
| dc.type | Artículo o Paper | es |
| umayor.indizador | COT | es |
| umayor.politicas.sherpa/romeo | Licence CC BY. Disponible en: http://sherpa.ac.uk/romeo/index.php | es |
| umayor.indexado | Web of Science | es |
| umayor.indexado | Scopus | es |
| dc.identifier.doi | 10.1111/jcpe.13282 | |
| umayor.indicadores.wos-(cuartil) | Q1 | |
| umayor.indicadores.scopus-(scimago-sjr) | H 141 | |
| umayor.indicadores.scopus-(scimago-sjr) | SJR 2.48 | |