| dc.contributor.author | Krasnow, Anna M. | |
| dc.contributor.author | Ford, Marc C. | |
| dc.contributor.author | Valdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile] | |
| dc.contributor.author | Wilson, Stephen W. | |
| dc.contributor.author | Attwell, David | |
| dc.date.accessioned | 2021-02-03T17:54:45Z | |
| dc.date.available | 2021-02-03T17:54:45Z | |
| dc.date.issued | 2018-01 | |
| dc.identifier.citation | Krasnow, A. M., Ford, M. C., Valdivia, L. E., Wilson, S. W., & Attwell, D. (2018). Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nature Neuroscience, 21(1), 24-28. | es |
| dc.identifier.issn | 1097-6256 | |
| dc.identifier.issn | eISSN: 1546-1726 | |
| dc.identifier.uri | http://repositorio.umayor.cl/xmlui/handle/sibum/7333 | |
| dc.identifier.uri | http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6478117&blobtype=pdf | |
| dc.identifier.uri | https://dx.doi.org/10.1038%2Fs41593-017-0031-y | |
| dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/pdf/emss-74889.pdf | |
| dc.description.abstract | How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development. | es |
| dc.description.sponsorship | We thank I.L. Arancibia-Carcamo, I. Bianco, E. Dreosti, V. Kyrargyri and W.T. Sherlock for comments, and we thank Fish Facility personnel for care of fish. This work was supported by a Wellcome Trust 4-year PhD studentship (099691/Z/12/Z) to A.M.K., an EU Marie Curie Fellowship (623714) to M.C.F., Wellcome Trust Investigator Awards to D.A. (099222/Z/12/Z) and S.W.W. (104682/Z/14/Z) and an MRC Programme grant (MR/L003775/1) to S.W.W. and G. Gestri. | es |
| dc.format.extent | 15 p., PDF | es |
| dc.language.iso | en_US | es |
| dc.publisher | NATURE PUBLISHING GROUP | es |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | es |
| dc.source | Nature Neuroscience, 21(1), 24-28 | |
| dc.subject | SYNAPTIC VESICLE RELEASE | es |
| dc.subject | INDIVIDUAL OLIGODENDROCYTES | es |
| dc.subject | CNS | es |
| dc.subject | CELLS | es |
| dc.subject | NEURONS | es |
| dc.subject | AXONS | es |
| dc.title | Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo | es |
| dc.type | Artículo o Paper | es |
| umayor.facultad | HUMANIDADES | |
| umayor.indizador | COT | es |
| umayor.politicas.sherpa/romeo | Esta obra está protegida bajo licencia de copyright | es |
| umayor.indexado | Web of Science | es |
| umayor.indexado | Scopus | es |
| umayor.indexado | WOS:000423155800009 | |
| umayor.indexado | PMID: 29230052 | |
| dc.identifier.doi | 10.1038/s41593-017-0031-y | |
| umayor.indicadores.wos-(cuartil) | Q1 | |
| umayor.indicadores.scopus-(scimago-sjr) | SJR 13.72 | |
| umayor.indicadores.scopus-(scimago-sjr) | SCIMAGO/ INDICE H: 398 H | |