Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
Date
2018-01Author
Krasnow, Anna M.
Ford, Marc C.
Valdivia, Leonardo E. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]
Wilson, Stephen W.
Attwell, David
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Abstract
How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca2+](i) transients and prevented by [Ca2+](i) buffering. Sheath elongation occurs similar to 1 h after [Ca2+](i) elevation. Sheath shortening is associated with a low frequency of [Ca2+](i) transients but with longer duration [Ca2+](i) bursts. Thus, [Ca2+](i) controls myelin sheath development.
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http://repositorio.umayor.cl/xmlui/handle/sibum/7333http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6478117&blobtype=pdf
https://dx.doi.org/10.1038%2Fs41593-017-0031-y
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478117/pdf/emss-74889.pdf
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