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El Repositorio Institucional de la Universidad Mayor, tiene como objetivo publicar, en formato digital, todos los objetos derivados de su producción científica, académica, cultural y artística. En palabras simples es una vitrina que pone en valor su patrimonio documental.
Silva-Pavez, E. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Ahumada-Castro, U. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Lovy, Alenka [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]; Cárdenas, Julio César [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile](Chile. Universidad Mayor, 2020)
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells ...
García-Huerta, Paula; Troncoso-Escudero, Paulina Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Wu, Di; Thiruvalluvan, Arun; Cisternas-Olmedo, Marisol [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez-Billault, Christian; Bergink, Steven; Vidal, Rene L.; Hetz, Claudio(SPRINGER, 2020-11)
Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Salvadores, Natalia [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Martínez, Alexis; Moreno-González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz, Claudio; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile](Chile. Universidad Mayor, 2020-07)
Correction to: Cell Death & Differentiation https://doi.org/10.1038/s41418-019-0408-4. Since online publication of this article, the authors noticed that reference details provided for references 65 and 66 were incorrect. ...
Cordero, Esteban M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortes, Bastian I. [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Palominos, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Parra, Pedro [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Mella, Tania [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henrríquez, Constanza [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Salazar, Nelda [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Monasterio, Gustavo; Cafferata, Emilio A.; Murgas, Paola [Centro de Biología Intergrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Vernal, Rolando; Cortez, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile](MDPI, 2020-05)
The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ...
Cancino, Gonzalo I. [Univ Mayor, Fac Ciencias, Ctr Integrat Biol]; Aranda-Pino, Begoña [Univ Mayor, Fac Ciencias, Ctr Integrat Biol]; Cornejo, Francisca [Univ Mayor, Fac Ciencias, Ctr Integrat Biol]; Tomita, Hideaki; Woodard, Cameron L.; Rioseco, Constanza C.; Neel, Benjamin G.; Alvarez, Alejandra R.; Kaplan, David R.; Miller, Freda D.(CELL PRESS, 2020)
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the ...
Cafferata, Emilio A.; Castro-Saavedra, Sebastián; Fuentes-Barros, Gonzalo; Melgar-Rodriguez, Samanta; Rivera, Felipe; Carvajal, Paola; Hernández, Marcela; Cortés, Bastian, I [Centro de Biología Integrativa, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cassels, Bruce K.; Vernal, Rolando(Chile. Universidad Mayor, 2020-06)
Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ...
Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. ...
Oñate, Maritza [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Catenaccio, Alejandra [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Salvadores, Natalia [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Saquel, Cristian [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile]; Martínez, Alexis; Moreno-González, Inés; Gamez, Nazaret; Soto, Paulina; Soto, Claudio; Hetz, Claudio; Court, Felipe A. [Ctr Integrat Biol, Fac Sci, Universidad Mayor, Chile](NATURE PUBLISHING GROUP, 2020-04)
Parkinson's disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ...
Slachevsky, Andrea; Zitko, Pedro; Martínez-Pernia, David; Forno, Gonzalo; Court, Felipe A. [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Lillo, Patricia; Villagra, Roque; Durán-Aniotz, Claudia; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibañez, Agustín; Parra, Mario A.; Gonzalez-Billault, Christian; Amieva, Helena; Thumala, Daniela(BioMed Central Ltd., 2020-12)
BackgroundWith the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and ...
Silva-Pavez, Eduardo [Univ Mayor, Fac Sci, Ctr Integrat Biol, Chile]; Tapia, Julio C.(Frontiers Media S.A., 2020-06)
Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ...