Listar Papers publicados por CBI por fecha de publicación
Mostrando ítems 41-60 de 85
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SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells
(Elsevier Inc., 2020-01)Brain tumours are among the deadliest tumours being highly resistant to currently available therapies. The proliferative behaviour of gliomas is strongly influenced by ion channel activity. Small-conductance calcium-activated ... -
Implications of Selective Autophagy Dysfunction for ALS Pathology
(MDPI Multidisciplinary Digital Publishing Institute, 2020-02)Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. ... -
Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation
(MDPI Multidisciplinary Digital Publishing Institute, 2020-02)Alzheimer's Disease (AD) is the primary cause of dementia among the elderly population. Elevated plasma levels of homocysteine (HCy), an amino acid derived from methionine metabolism, are considered a risk factor and ... -
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
(NATURE PUBLISHING GROUP, 2020-04)Parkinson's disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ... -
Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes
(MDPI, 2020-05)The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ... -
Decoding Gene Networks Modules That Explain the Recovery of Hymenoglossum cruentum Cav. After Extreme Desiccation
(Frontiers Media S.A., 2020-05)Hymenoglossum cruentum (Hymenophyllaceae) is a poikilohydric, homoiochlorophyllous desiccation-tolerant (DT) epiphyte fern. It can undergo fast and frequent dehydration-rehydration cycles. This fern is highly abundant at ... -
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca(2+)Transfer to Mitochondria
(Frontiers Media S.A., 2020-05)Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca(2+)regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously ... -
Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance
(Chile. Universidad Mayor, 2020-06)Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ... -
Protein Kinase CK2 in Cancer Energetics
(Frontiers Media S.A., 2020-06)Protein kinase CK2 (formerly known as casein kinase 2) is abnormally elevated in many cancers. This may increase tumor aggressiveness through CK2-dependent phosphorylation of key proteins in several signaling pathways. In ... -
Schwann cell reprogramming into repair cells increases miRNA-21 expression in exosomes promoting axonal growth
(Company of Biologists Ltd, 2020-06)Functional recovery after peripheral nerve damage is dependent on the reprogramming of differentiated Schwann cells (dSCs) into repair Schwann cells (rSCs), which promotes axonal regeneration and tissue homeostasis. ... -
Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (vol 32, pg 274, 2019)
(Chile. Universidad Mayor, 2020-07)Correction to: Cell Death & Differentiation https://doi.org/10.1038/s41418-019-0408-4. Since online publication of this article, the authors noticed that reference details provided for references 65 and 66 were incorrect. ... -
Phosphorylation of Endothelin-Converting Enzyme-1c at Serines 18 and 20 by CK2 Promotes Aggressiveness Traits in Colorectal Cancer Cells
(Frontiers Media S.A., 2020-07)Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. ... -
Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival
(American Association for the Advancement of Science, 2020-07)Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ... -
The necroptosis pathway and its role in age-related neurodegenerative diseases: will it open up new therapeutic avenues in the next decade?
(Taylor and Francis Ltd., 2020-07)Introduction: Necroptosis is a programmed form of necrotic cell death. Growing evidence demonstrates that necroptosis contributes to cell demise in different pathological conditions including age-dependent neurodegenerative ... -
Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer's Disease
(Frontiers Media S.A., 2020-08)Nicotinamide (vitamin B3) is a key component in the cellular production of Nicotinamide Adenine Dinucleotide (NAD) and has long been associated with neuronal development, survival and death. Numerous data suggest that ... -
Metformin protects from oxaliplatin induced peripheral neuropathy in rats
(Elsevier BV, 2020-08)Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients ... -
P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis
(Nature Publishing Group, 2020-09)P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF ... -
The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging
(Frontiers Media S.A., 2020-09)Aging is the time-dependent functional decline that increases the vulnerability to different forms of stress, constituting the major risk factor for the development of neurodegenerative diseases. Dysfunctional mitochondria ... -
On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson's and Huntington's Disease
(Frontiers Media S.A., 2020-09)Movement disorders are neurological conditions in which patients manifest a diverse range of movement impairments. Distinct structures within the basal ganglia of the brain, an area involved in movement regulation, are ... -
Axonal Degeneration in AD: The Contribution of A beta and Tau
(Frontiers Media S.A., 2020-10)Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder, affecting around 35 million people worldwide. Despite enormous efforts dedicated to AD research over decades, there is still no ...