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    P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis

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    Date
    2020-09
    Author

    Wisniewski, Laura

    French, Vanessa

    Lockwood, Nicola

    Valdivia, Leonardo E. [Univ Mayor, Ctr Integrat Biol, Fac Sci, Chile]

    Frankel, Paul

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    Abstract
    P130CAS/BCAR1 belongs to the CAS family of adaptor proteins, with important regulatory roles in cell migration, cell cycle control, and apoptosis. Previously, we and others showed that P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remains relatively unexplored. We characterise here a novel deletion model of P130CAS in zebrafish. Using in vivo microscopy and transgenic vascular reporters, we observed that while bcar1-/- zebrafish showed no arterial angiogenic or heart defects during development, they strikingly failed to form the caudal vein plexus (CVP). Endothelial cells (ECs) within the CVP of bcar1-/- embryos produced fewer filopodial structures and did not detach efficiently from neighbouring cells, resulting in a significant reduction in ventral extension and overall CVP area. Mechanistically, we show that P130Cas mediates Bmp2b-induced ectopic angiogenic sprouting of ECs in the developing embryo and provide pharmacological evidence for a role of Src family kinases in CVP development.
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    http://repositorio.umayor.cl/xmlui/handle/sibum/8519
    https://discovery.ucl.ac.uk/id/eprint/10112264/1/s41598-020-71753-w.pdf
    https://discovery.ucl.ac.uk/id/eprint/10112264/1/s41598-020-71753-w.pdf
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518251/pdf/41598_2020_Article_71753.pdf
    https://dx.doi.org/10.1038%2Fs41598-020-71753-w
    https://www.nature.com/articles/s41598-020-71753-w.pdf
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    Modificado por: Sistema de Bibliotecas Universidad Mayor - SIBUM
    DSpace software copyright © 2002-2018  DuraSpace