Listar Centro de Investigación en Genómica y Bioinformática (CGB) por fecha de publicación
Mostrando ítems 41-60 de 80
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Implications of Selective Autophagy Dysfunction for ALS Pathology
(MDPI Multidisciplinary Digital Publishing Institute, 2020-02)Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. ... -
Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar)
(Frontiers Media S.A., 2020-02-27)Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ... -
Bacterially produced metabolites protect C. elegans neurons from degeneration
(Public Library of Science, 2020-03)Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains ... -
Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade
(Nature Publishing Group, 2020-03-02)Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly respond to environmental perturbation. However, the underlying transient interactions between transcription factors (TFs) and genome-wide ... -
Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
(Blackwell Munksgaard, 2020-04)Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ... -
Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus
(MDPI Multidisciplinary Digital Publishing Institute, 2020-04)Organisms that thrive in extremely acidic environments (<= pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely ... -
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
(Nature Publishing Group, 2020-04-28)Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ... -
Draft Genome Sequence of Blautia luti DSM 14534(T), Isolated from Human Stool
(Chile. Universidad Mayor, 2020-05)Here, we report the draft sequence of Blautia luti strain DSM 14534T, originally isolated from human feces. This draft contains 74 contigs, comprising 3,718,760 bp with a G+C content of 42.87%. The annotated draft contains ... -
Interfering with the Folding of Group A Streptococcal pili Proteins
(Chile. Universidad Mayor, 2020-05-20)Gram-positive bacteria use their adhesive pili to attach to host cells during early stages of a bacterial infection. These extracellular hair-like appendages experience mechanical stresses of hundreds of picoNewtons; ... -
Nutrient dose-responsive transcriptome changes driven by Michaelis Menten kinetics underlie plant growth rates
(National Academy of Sciences, 2020-06-09)An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes ... -
Nitrate in 2020: Thirty Years from Transport to Signaling Networks
(American Society of Plant Biologists, 2020-07)Nitrogen (N) is an essential macronutrient for plants and a major limiting factor for plant growth and crop production. Nitrate is the main source of N available to plants in agricultural soils and in many natural environments. ... -
Dormant but Active: Chilling Accumulation Modulates the Epigenome and Transcriptome ofPrunus aviumDuring Bud Dormancy
(Frontiers Media S.A., 2020-07)Temperate deciduous fruit tree species like sweet cherry (Prunus avium) require long periods of low temperatures to trigger dormancy release and flowering. In addition to sequence-based genetic diversity, epigenetic variation ... -
A balancing act: how plants integrate nitrogen and water signals
(Oxford University Press, 2020-07-25)Nitrogen (N) and water (W) are crucial inputs for plant survival as well as costly resources for agriculture. Given their importance, the molecular mechanisms that plants rely on to signal changes in either N or W status ... -
Deciphering the functional diversity of DNA-binding transcription factors in Bacteria and Archaea organisms
(Public Library of Science, 2020-08)DNA-binding Transcription Factors (TFs) play a central role in regulation of gene expression in prokaryotic organisms, and similarities at the sequence level have been reported. These proteins are predicted with different ... -
Gene Regulatory Networks of Penicillium echinulatum 2HH and Penicillium oxalicum 114-2 Inferred by a Computational Biology Approach
(Frontiers Media S.A., 2020-10)Penicillium echinulatum 2HH and Penicillium oxalicum 114-2 are well-known cellulase fungal producers. However, few studies addressing global mechanisms for gene regulation of these two important organisms are available so ... -
AciDB 1.0: a database of acidophilic organisms, their genomic information and associated metadata
(OXFORD UNIV PRESS, 2020-10-01)Motivation: There are about 600 available genome sequences of acidophilic organisms (grow at a pH<5) from the three domains of the Tree of Life. Information about acidophiles is scattered over many heterogeneous sites ... -
Non-Specific Antibodies Induce Lysosomal Activation in Atlantic Salmon Macrophages Infected by Piscirickettsia salmonis
(Frontiers Media S.A., 2020-11)Piscirickettsia salmonis, an aggressive intracellular pathogen, is the etiological agent of salmonid rickettsial septicemia (SRS). This is a chronic multisystemic disease that generates high mortalities and large losses ... -
The Microbial Composition in Circumneutral Thermal Springs from Chignahuapan, Puebla, Mexico Reveals the Presence of Particular Sulfur-Oxidizing Bacterial and Viral Communities
(MDPI AG, 2020-11)Terrestrial thermal springs are widely distributed globally, and these springs harbor a broad diversity of organisms of biotechnological interest. In Mexico, few studies exploring this kind of environment have been described. ... -
Unlocking Survival Mechanisms for Metal and Oxidative Stress in the Extremely Acidophilic, Halotolerant Acidihalobacter Genus
(MDPI Multidisciplinary Digital Publishing Institute, 2020-11-24)Microorganisms used for the biohydrometallurgical extraction of metals from minerals must be able to survive high levels of metal and oxidative stress found in bioleaching environments. The Acidihalobacter genus consists ... -
Genome-based classification of Acidihalobacter prosperus F5 (=DSM 105917=JCM 32255) as Acidihalobacter yilgarnensis sp. nov
(MICROBIOLOGY SOCIETY, 2020-12)The genus Acidihalobacter has three validated species, Acidihalobacter ferrooxydans, Acidihalobacter prosperus and Acidihalobacter aeolinanus, all of which were isolated from Vulcano island, Italy. They are obligately ...