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Inhibitory effect of serotype a of Aggregatibacter actinomycetemcomitans on the increased destructive potential of serotype b
(WILEY, 2020)
Objective The serotype b of Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) induces higher cytokine production in dendritic cells (DCs) compared with the other serotypes. However, this increased immunostimulatory ...
Pleione: A tool for statistical and multi-objective calibration of Rule-based models
(NATURE PUBLISHING GROUP, 2019)
Mathematical models based on Ordinary Differential Equations (ODEs) are frequently used to describe and simulate biological systems. Nevertheless, such models are often difficult to understand. Unlike ODE models, Rule-Based ...
Gadolinium Chloride Rescues Niemann-Pick Type C Liver Damage
(MDPI, 2018)
Niemann-Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the NPC1 or NPC2 genes. Soon after birth, some patients present with an aggressive ...
Improved ontology for eukaryotic single-exon coding sequences in biological databases
(OXFORD UNIV PRESS, 2018)
Efficient extraction of knowledge from biological data requires the development of structured vocabularies to unambiguously define biological terms. This paper proposes descriptions and definitions to disambiguate the term ...
Identification of Modules With Similar Gene Regulation and Metabolic Functions Based on Co-expression Data
(FRONTIERS MEDIA SA, 2019)
Biological systems respond to environmental perturbations and to a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. In particular, a wide variety of gene co-expression ...
Genome-based classification of Acidihalobacter prosperus F5 (=DSM 105917=JCM 32255) as Acidihalobacter yilgarnensis sp. nov
(MICROBIOLOGY SOCIETY, 2020-12)
The genus Acidihalobacter has three validated species, Acidihalobacter ferrooxydans, Acidihalobacter prosperus and Acidihalobacter aeolinanus, all of which were isolated from Vulcano island, Italy. They are obligately ...
Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
(Chile. Universidad Mayor, 2019-10-16)
Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ...
AciDB 1.0: a database of acidophilic organisms, their genomic information and associated metadata
(OXFORD UNIV PRESS, 2020-10-01)
Motivation: There are about 600 available genome sequences of acidophilic organisms (grow at a pH<5) from the three domains of the Tree of Life. Information about acidophiles is scattered over many heterogeneous sites ...
Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar)
(Frontiers Media S.A., 2020-02-27)
Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ...
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
(Nature Publishing Group, 2020-04-28)
Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ...