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Inhibitory effect of serotype a of Aggregatibacter actinomycetemcomitans on the increased destructive potential of serotype b
(WILEY, 2020)
Objective The serotype b of Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) induces higher cytokine production in dendritic cells (DCs) compared with the other serotypes. However, this increased immunostimulatory ...
Genome-based classification of Acidihalobacter prosperus F5 (=DSM 105917=JCM 32255) as Acidihalobacter yilgarnensis sp. nov
(MICROBIOLOGY SOCIETY, 2020-12)
The genus Acidihalobacter has three validated species, Acidihalobacter ferrooxydans, Acidihalobacter prosperus and Acidihalobacter aeolinanus, all of which were isolated from Vulcano island, Italy. They are obligately ...
AciDB 1.0: a database of acidophilic organisms, their genomic information and associated metadata
(OXFORD UNIV PRESS, 2020-10-01)
Motivation: There are about 600 available genome sequences of acidophilic organisms (grow at a pH<5) from the three domains of the Tree of Life. Information about acidophiles is scattered over many heterogeneous sites ...
Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar)
(Frontiers Media S.A., 2020-02-27)
Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ...
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
(Nature Publishing Group, 2020-04-28)
Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ...
Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
(Blackwell Munksgaard, 2020-04)
Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ...
Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus
(MDPI Multidisciplinary Digital Publishing Institute, 2020-04)
Organisms that thrive in extremely acidic environments (<= pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely ...
Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade
(Nature Publishing Group, 2020-03-02)
Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly respond to environmental perturbation. However, the underlying transient interactions between transcription factors (TFs) and genome-wide ...
Nutrient dose-responsive transcriptome changes driven by Michaelis Menten kinetics underlie plant growth rates
(National Academy of Sciences, 2020-06-09)
An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes ...
Unlocking Survival Mechanisms for Metal and Oxidative Stress in the Extremely Acidophilic, Halotolerant Acidihalobacter Genus
(MDPI Multidisciplinary Digital Publishing Institute, 2020-11-24)
Microorganisms used for the biohydrometallurgical extraction of metals from minerals must be able to survive high levels of metal and oxidative stress found in bioleaching environments. The Acidihalobacter genus consists ...