Centro de Investigación en Genómica y Bioinformática (CGB): Envíos recientes
Mostrando ítems 41-60 de 80
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Rule-Based Models and Applications in Biology
(Humana Press, 2018-11-13)Complex systems are governed by dynamic processes whose underlying causal rules are difficult to unravel. However, chemical reactions, molecular interactions, and many other complex systems can be usually represented as ... -
The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains
(Public Library of Science, 2019-12-19)In this work, we describe a systematic comparative genomic analysis of promiscuous domains in genomes of Bacteria and Archaea. A quantitative measure of domain promiscuity, the weighted domain architecture score (WDAS), ... -
Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar)
(Frontiers Media S.A., 2020-02-27)Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ... -
Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis
(Blackwell Munksgaard, 2020-04)Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ... -
Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus
(MDPI Multidisciplinary Digital Publishing Institute, 2020-04)Organisms that thrive in extremely acidic environments (<= pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely ... -
A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues
(Nature Publishing Group, 2020-04-28)Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ... -
Draft Genome Sequence of Blautia luti DSM 14534(T), Isolated from Human Stool
(Chile. Universidad Mayor, 2020-05)Here, we report the draft sequence of Blautia luti strain DSM 14534T, originally isolated from human feces. This draft contains 74 contigs, comprising 3,718,760 bp with a G+C content of 42.87%. The annotated draft contains ... -
Unlocking Survival Mechanisms for Metal and Oxidative Stress in the Extremely Acidophilic, Halotolerant Acidihalobacter Genus
(MDPI Multidisciplinary Digital Publishing Institute, 2020-11-24)Microorganisms used for the biohydrometallurgical extraction of metals from minerals must be able to survive high levels of metal and oxidative stress found in bioleaching environments. The Acidihalobacter genus consists ... -
Interfering with the Folding of Group A Streptococcal pili Proteins
(Chile. Universidad Mayor, 2020-05-20)Gram-positive bacteria use their adhesive pili to attach to host cells during early stages of a bacterial infection. These extracellular hair-like appendages experience mechanical stresses of hundreds of picoNewtons; ... -
Nutrient dose-responsive transcriptome changes driven by Michaelis Menten kinetics underlie plant growth rates
(National Academy of Sciences, 2020-06-09)An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes ... -
Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade
(Nature Publishing Group, 2020-03-02)Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly respond to environmental perturbation. However, the underlying transient interactions between transcription factors (TFs) and genome-wide ... -
A balancing act: how plants integrate nitrogen and water signals
(Oxford University Press, 2020-07-25)Nitrogen (N) and water (W) are crucial inputs for plant survival as well as costly resources for agriculture. Given their importance, the molecular mechanisms that plants rely on to signal changes in either N or W status ... -
Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
(Chile. Universidad Mayor, 2019-10-16)Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ... -
Draft genome of Chilean honeybee (Apis mellifera) gut strain Lactobacillus kunkeei MP2
(American Society for Microbiology, 2014)Here, we report the first draft genome sequence of Lactobacillus kunkeei strain MP2, isolated from a Chilean honeybee gut. The sequenced genome has a total size of 1.58 Mb distributed into 44 contigs and 1,356 protein-coding ... -
Inhibitory effect of serotype a of Aggregatibacter actinomycetemcomitans on the increased destructive potential of serotype b
(WILEY, 2020)Objective The serotype b of Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) induces higher cytokine production in dendritic cells (DCs) compared with the other serotypes. However, this increased immunostimulatory ... -
Pleione: A tool for statistical and multi-objective calibration of Rule-based models
(NATURE PUBLISHING GROUP, 2019)Mathematical models based on Ordinary Differential Equations (ODEs) are frequently used to describe and simulate biological systems. Nevertheless, such models are often difficult to understand. Unlike ODE models, Rule-Based ... -
Identification of Modules With Similar Gene Regulation and Metabolic Functions Based on Co-expression Data
(FRONTIERS MEDIA SA, 2019)Biological systems respond to environmental perturbations and to a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. In particular, a wide variety of gene co-expression ... -
Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans
(NATURE PUBLISHING GROUP, 2019)Whole human genome sequencing initiatives help us understand population history and the basis of genetic diseases. Current data mostly focuses on Old World populations, and the information of the genomic structure of Native ... -
Intermediate-Salinity Systems at High Altitudes in the Peruvian Andes Unveil a High Diversity and Abundance of Bacteria and Viruses
(MDPI, 2019)Intermediate-salinity environments are distributed around the world. Here, we present a snapshot characterization of two Peruvian thalassohaline environments at high altitude, Maras and Acos, which provide an excellent ... -
Tracing the phylogenetic history of the Crl regulon through the Bacteria and Archaea genomes
(BMC, 2019)Background: Crl, identified for curli production, is a small transcription factor that stimulates the association of the sigma(S) factor (RpoS) with the RNA polymerase core through direct and specific interactions, increasing ...