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dc.contributorUniv Mayor, Ctr Fisiol Del Ejercicio, Chilees
dc.contributor.authorJain, Vivek
dc.contributor.authorKimbro, Shawn
dc.contributor.authorKowalik, Grant
dc.contributor.authorMilojevic, Ivana
dc.contributor.authorDowling, N. Maritza
dc.contributor.authorHunley, Anne Lloyd
dc.contributor.authorHauser, Kelsey
dc.contributor.authorAndrade, David C. [Univ Mayor, Fac Ciencias, Ctr Invest Fisiol Ejercicio, Chile]
dc.contributor.authorDel Rio, Rodrigo
dc.contributor.authorKay, Matthew W.
dc.contributor.authorMendelowitz, David
dc.date.accessioned2022-02-24T01:41:29Z
dc.date.available2022-02-24T01:41:29Z
dc.date.issued2020-10
dc.identifier.citationJain, V., Kimbro, S., Kowalik, G., Milojevic, I., Dowling, N. M., Hunley, A. L., ... & Mendelowitz, D. (2020). Intranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo controlled study. Sleep Medicine, 74, 242-247.es
dc.identifier.issn1389-9457
dc.identifier.issneISSN: 1878-5506
dc.identifier.otherWOS: 000577126500036
dc.identifier.otherPMID: 32862007
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/8310
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S1389945720302446?via%3Dihub
dc.identifier.urihttps://doi.org/10.1016/j.sleep.2020.05.034
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32862007/
dc.description.abstractBackground: Activation of the oxytocin network has shown benefits in animal models of Obstructive Sleep Apnea (OSA) as well as other cardiorespiratory diseases. We sought to determine if nocturnal intranasal oxytocin administration could have beneficial effects in reducing the duration and/or frequency of obstructive events in obstructive sleep apnea subjects. Methods: Two sequential standard "in-lab" polysomnogram (PSG) sleep studies were performed in patients diagnosed with OSA that were randomly assigned to initially receive either placebo or oxytocin (40 i.u.) administered intranasally in this double blinded randomized placebo controlled study. Changes in cardiorespiratory events during sleep, including apnea and hypopnea durations and frequency, risk of event-associated bradycardias, arterial oxygen desaturation and respiratory rate were assessed in 2 h epochs following sleep onset. Oxytocin significantly decreased the duration of obstructive events, as well as the oxygen desaturations and incidence of bradycardia that were associated with these events. Notably, oxytocin increased respiratory rate during non-obstructive periods. There were no significant changes in sleep architecture and no adverse effects were reported. Conclusions: Oxytocin administration can benefit OSA subjects by reducing the duration and adverse consequences of obstructive events. Oxytocin could also be beneficial in situations involving respiratory depression as oxytocin increased respiratory rate. Additional studies are needed to further understand the mechanisms by which oxytocin promotes these changes in cardiorespiratory function. The long-term efficacy and optimal dose of intranasal oxytocin treatment should also be determined in OSA subjects. (C) 2020 Elsevier B.V. All rights reserved.es
dc.description.sponsorshipInstitutional funds from the George Washington University School of Medicine and Health Sciences, Medical Faculty Associates and a GWU Cross-Disciplinary Research Grant are gratefully acknowledged.es
dc.format.extent6 p., PDFes
dc.language.isoen_USes
dc.publisherElsevieres
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees
dc.titleIntranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo controlled studyes
dc.typeArtículo o Paperes
umayor.indizadorCOTes
umayor.politicas.sherpa/romeoLicencia CC BY-NC-ND 4.0. Disponible en: https://v2.sherpa.ac.uk/id/publication/12947es
umayor.indexadoWeb of Sciencees
umayor.indexadoPUBMEDes
dc.identifier.doi10.1016/j.sleep.2020.05.034
umayor.indicadores.wos-(cuartil)Q2
umayor.indicadores.scopus-(scimago-sjr)SCIMAGO/ INDICE H: 122 H
umayor.indicadores.scopus-(scimago-sjr)SJR 1.34


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