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dc.contributorWILEY-BLACKWELLes_CL
dc.contributor.authorKwon,Yoon-Jeoung [Universidad de Chile]es_CL
dc.contributor.authorAlliende, Cecilia [Universidad de Chile]es_CL
dc.contributor.authorLeyton,Lisette [Universidad de Chile]es_CL
dc.contributor.authorAguilera, Sergio [Chile. Universidad Andrés Bello]es_CL
dc.contributor.authorMolina, Claudio [Chile. Universidad Mayor]es_CL
dc.contributor.authorLabra, Cecilia [Universidad de Chile]es_CL
dc.date.accessioned2018-09-07T14:11:39Z
dc.date.available2018-09-07T14:11:39Z
dc.date.issued2005es_CL
dc.identifier.citationPérez P, Kwon YJ, Alliende C, Leyton L, Aguilera S, Molina C, Labra C, Julio M, Leyton C, González MJ. Increased acinar damage of salivary glands of patients with Sjögren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratios. Arthritis Rheum. 2005 Sep;52(9):2751-60. PubMed PMID: 16142742.es_CL
dc.identifier.issnISSN 0004-3591es_CL
dc.identifier.issnESSN 1529-0131es_CL
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/art.21265es_CL
dc.identifier.urihttps://doi.org/10.1002/art.21265es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/2707
dc.description.abstractOBJECTIVE: Previous findings in labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) suggest that increased activity and expression of matrix metalloproteinase 9 (MMP-9) and MMP-3 trigger the destruction of acinar structures in these glands. Tissue inhibitors of matrix metalloproteinases (TIMPs) tightly control MMP activity, and TIMP expression is an important modulator of effects attributed to MMPs. This study was undertaken to investigate the correlation between the balance of MMPs/TIMPs in the LSGs of SS patients and the degree of inflammatory infiltration and acinar structure integrity. METHODS: Three groups of SS patients classified according to focus score and residual tissue were studied. The expression of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 was examined at the messenger RNA and protein levels. The ratio of MMP/TIMP expression (R value) was calculated. Focus score and acinar structure were evaluated by histologic analysis. RESULTS: In SS patients the MMP-3/TIMP-1 ratio was higher than 1 and the MMP-9/TIMP-1 ratio was much higher than 1 whereas the MMP-2/TIMP-2 ratio nearly equaled 1, suggesting elevated proteolytic activity due mainly to MMP-9. R values were independent of the focus score of inflammatory cells, but correlated well with the dramatic changes observed in morphologic integrity of acini, as revealed mainly by the lack of nuclear polarity. Acinar changes were more evident when R values for both MMP-9/TIMP-1 and MMP-3/TIMP-1 were higher. CONCLUSION: This study provides evidence that an altered balance between MMPs and their inhibitors is associated with acinar damage. Since salivary gland acinar cells express both MMPs and TIMPs, these cells may play an important role in extracellular matrix destruction and in the LSG pathophysiology in SS.es_CL
dc.description.sponsorshipEste trabajo no contó con financiamiento.es_CL
dc.format.extentARTÍCULO ORIGINALes_CL
dc.language.isoenes_CL
dc.publisherCIENCIASes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees_CL
dc.subjectREUMATOLOGÍAes_CL
dc.titleIncreased acinar damage of salivary glands of patients with Sjogren's syndrome is paralleled by simultaneous imbalance of matrix metalloproteinase 3/tissue inhibitor of metalloproteinases 1 and matrix metalloproteinase 9/tissue inhibitor of metalloproteinases 1 ratioses_CL
dc.typeArtículo o Paperes_CL
umayor.indizadorCOTes_CL
umayor.politicas.sherpa/romeoLicencia color: AMARILLO (Puede archivar el pre-print (ie la versión previa a la revisión por pares))--Pre-print del autor: el autor puede archivar la versión pre-print (ie la versión previa a la revisión por pares) Post-print del autor: el autor puede archivar la versión post-print (ie la versión final posterior a la revisión por pares) siempre que se cumplan las restricciones: 12 months embargo for scientific, technical and medicine titles, 2 years embargo for humanities and social science titles Versión de editor/PDF: el autor no puede archivar la versión del editor/PDF. Condiciones generales: Algunas revistas tienen políticas independientes, consultar directamente con cada revista, On author's personal website, institutional repositories, arXiv, AgEcon, PhilPapers, PubMed Central, RePEc or Social Science Research Network, Author's pre-print may not be updated with Publisher's Version/PDF, Author's pre-print must acknowledge acceptance for publication, En un servidor sin ánimo de lucro, La versión de editor/PDF no puede utilizarse, Debe reconocerse la fuente de publicación con la cita, Must link to publisher version with set statement (see policy), If OnlineOpen is available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 12 months, If OnlineOpen is not available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 6 months, If OnlineOpen is available, AHRC and ESRC authors, may self-archive after 24 months, If OnlineOpen is not available, AHRC and ESRC authors, may self-archive after 12 months// Disponible en: http://www.sherpa.ac.uk/romeo/issn/0004-3591/es/es_CL
umayor.indexadoWOSes_CL
dc.identifier.doi10.1002/art.21265es_CL]
umayor.indicadores.wos-(cuartil)Q1es_CL
umayor.indicadores.scopus-(scimago-sjr)sin informaciónes_CL


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