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dc.contributorSpandidos Publ.es_CL
dc.contributor.authorAlfaro-Lira, Susana [Chile. Universidad de Tarapacá]es_CL
dc.contributor.authorBrown, Nelson [Chile.Universidad de Talca]es_CL
dc.contributor.authorSalas, Cristián O. [Pontificia Universidad Católica de Chile]es_CL
dc.contributor.authorCuellar, Mauricio [Chile. Universidad de Valparaíso]es_CL
dc.contributor.authorSantander, Javier [Chile. Universidad Mayor. Centro de Genómica y Bioinformática]es_CL
dc.contributor.authorPablo Ogalde, Juan [Chile. Universidad de Tarapacá]es_CL
dc.date.accessioned2018-09-07T14:11:47Z
dc.date.available2018-09-07T14:11:47Z
dc.date.issued2014es_CL
dc.identifier.citationEchiburú-Chau, C., Alfaro-Lira, S., Brown, N., Salas, C.O., Cuellar, M., Santander, J. ... Rothhammer, F. (2014). The selective cytotoxicity elicited by phytochemical extract from Senecio graveolens (Asteraceae) on breast cancer cells is enhanced by hypoxia. International Journal of Oncology, 44, 1357-1364. https://doi.org/10.3892/ijo.2014.2302es_CL
dc.identifier.issnISSN 1019-6439es_CL
dc.identifier.issnESSN 1791-2423es_CL
dc.identifier.urihttps://www.spandidos-publications.com/ijo/44/4/1357/downloades_CL
dc.identifier.urihttps://doi.org/10.3892/ijo.2014.2302es_CL
dc.identifier.urihttp://repositorio.umayor.cl/xmlui/handle/sibum/2791
dc.description.abstractBreast cancer is the second cause of cancer related deaths in woman and the incidence of the disease has increased worldwide, in part due to improvements in early detection. Several drugs with anticancer effects have been extracted from plants in the last 20 years, many of which are particularly effective against breast cancer cells. In particular, we have become interested in the ethanolic extract from Senecio graveolens (synonym of S. nutans), a plant commonly called Chachacoma, in an effort to isolate compounds that could demonstrate cytotoxic effects on breast cancer cells. Senecio (Asteraceae) is the largest gender in Chile comprising approximatly 200 species. These herbs inhabit areas over 3,500 meters above the sea level in the Andes Mountains. S. graveolens is commonly used by local communities for its medicinal properties, particularly its capacity to ameliorate high-altitude-associated sickness. The cytotoxic effect of the alcoholic extract from S. graveolens, as well as its most abundant compound 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone, were tested in the breast cancer cell lines ZR-75-1, MCF-7 and MDA-MB 231, and non-tumorigenic MCF-10F cells. We show that the phytochemical extract was able to induce cytotoxicity in cancer cells but not in MCF-10F. Importantly, this effect was enhanced under hypoxic conditions. However, 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone, the main compound, did not by itself show an effective anticarcinogenic activity in comparison to the whole extract. Interestingly, the cytotoxic effect of the phytochemical extract was dependent on the basal MnSOD protein expression. Thus, cytotoxicity was increased when MnSOD levels were low, but resistance was evident when protein levels were high. Additionally, the crude extract seems to trigger cell death by a variety of processes, including autophagy, apoptosis and necrosis, in MCF-7 cells. In summary, S. graveolens extract possess anticancer activity displaying a specific cytotoxic effect on cancer cells, thus serving as a potential source of phytochemical compounds for cancer treatment.es_CL
dc.description.sponsorshipEste trabajo fue financiado por: Grant FONDECYT 11110284, CECH y CODECITE-CIHDE.es_CL
dc.format.extentARTÍCULO ORIGINALes_CL
dc.language.isoenes_CL
dc.publisherCIENCIASes_CL
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chilees_CL
dc.subjectONCOLOGÍAes_CL
dc.titleThe selective cytotoxicity elicited by phytochemical extract from Senecio graveolens ( Asteraceae) on breast cancer cells is enhanced by hypoxiaes_CL
dc.typeArtículo o Paperes_CL
umayor.indizadorCOTes_CL
umayor.politicas.sherpa/romeoLicencia color: BLANCO (El archivo no está formalmente admitido)--Pre-print del autor: el autor no puede archivar la versión pre-print (ie la versión previa a la revisión por pares) Post-print del autor: el autor no puede archivar la versión post-print (ie la versión final posterior a la revisión por pares) Versión de editor/PDF: el autor puede archivar la versión PDF de la editorial siempre que se cumplan las restricciones: 6 meses de embargo Condiciones generales: La versión de editor/PDF debe utilizarse, On Institutional Repository or Funder's repository, Debe ir enlazado a la versión de editor, La fuente publicada debe reconocerse con la cita completa, Publisher will automatically deposit authors post-print in PubMed Central or Europe PMC after 6 months or 12 months as required by funding agency// Disponible en: http://www.sherpa.ac.uk/romeo/issn/1019-6439/es/es_CL
umayor.indexadoWOSes_CL
umayor.indexadoSCOPUSes_CL
dc.identifier.doi10.3892/ijo.2014.2302es_CL]
umayor.indicadores.wos-(cuartil)Q2es_CL
umayor.indicadores.scopus-(scimago-sjr)sin informaciónes_CL


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