Centro de Biología Integrativa (CBI): Envíos recientes
Mostrando ítems 41-60 de 88
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Ca2+ transfer to mitochondria: a spark of life in unexpected conditions
(Chile. Universidad Mayor, 2020)The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells ... -
Conversatorio: Hacia el envejecimiento saludable en Chile
(Chile. Universidad Mayor, 2021-01-21)El conversatorio en línea "Hacia el envejecimiento saludable en Chile" organizado por la Facultad de Ciencias de la Universidad Mayor y Abbott, compañía multinacional de alta tecnología en salud. En la convocatoria, ... -
La Ruta del Pensamiento: una mirada actual al cáncer en Chile
(Chile. Universidad Mayor, 2021-08-20)El Doctor en Ciencias Biológicas e investigador del Centro de Biología Integrativa de la Universidad Mayor, Erick Riquelme, aborda el proceso de los tumores, los principales tratamientos, los últimos hallazgos para futuros ... -
La Ruta del Pensamiento: ¿Qué sabemos de las enfermedades que afectan al cerebro?
(Chile. Universidad Mayor, 2021-07-28)René Vidal, Doctor en Ciencias y académico del Centro de Biología Integrativa U. Mayor, realizó el webinar “¿Qué sabemos de las enfermedades que afectan al cerebro?”, donde profundizó en su funcionamiento y qué ocurre ... -
Teased Fiber Preparation of Myelinated Nerve Fibers from Peripheral Nerves for Vital Dye Staining and Immunofluorescence Analysis
(Humana Press, 2018)Glial cells regulate a wide variety of neuronal functions during physiological and pathological conditions. Therefore, the study of glial cells and their association with axons is of paramount importance in order to ... -
Purification of Exosomes from Primary Schwann Cells, RNA Extraction, and Next-Generation Sequencing of Exosomal RNAs
(Humana Press, 2018)Exosomes are small (30-150 nm) vesicles of endosomal origin secreted by most cell types. Exosomes contain proteins, lipids, and RNA species including microRNA, mRNA, rRNA, and long noncoding RNAs. The mechanisms associated ... -
In Vitro Analysis of the Role of Schwann Cells on Axonal Degeneration and Regeneration Using Sensory Neurons from Dorsal Root Ganglia
(Humana Press, 2018)Sensory neurons from dorsal root ganglion efficiently regenerate after peripheral nerve injuries. These neurons are widely used as a model system to study degenerative mechanisms of the soma and axons, as well as regenerative ... -
A dual role for Integrin alpha 6 beta 4 in modulating hereditary neuropathy with liability to pressure palsies
(WILEY, 2018-05)Peripheral myelin protein 22 (PMP22) is a component of compact myelin in the peripheral nervous system. The amount of PMP22 in myelin is tightly regulated, and PMP22 over or under-expression cause Charcot-Marie-Tooth 1A ... -
Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo
(NATURE PUBLISHING GROUP, 2018-01)How action potentials regulate myelination by oligodendrocytes is uncertain. We show that neuronal activity raises [Ca2+](i) in developing oligodendrocytes in vivo and that myelin sheath elongation is promoted by a high ... -
The Enigmatic Role of C9ORF72 in Autophagy
(FRONTIERS MEDIA SA, 2017-08-03)Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and ... -
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates
(SPRINGER, 2020-11)Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ... -
Correction: The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease (vol 32, pg 274, 2019)
(Chile. Universidad Mayor, 2020-07)Correction to: Cell Death & Differentiation https://doi.org/10.1038/s41418-019-0408-4. Since online publication of this article, the authors noticed that reference details provided for references 65 and 66 were incorrect. ... -
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
(NATURE PUBLISHING GROUP, 2020-04)Parkinson's disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ... -
Axonal Degeneration Is Mediated by Necroptosis Activation
(SOC NEUROSCIENCE, 2019-05-15)Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated ... -
Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2019-08)Sin resumen. -
Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance
(Chile. Universidad Mayor, 2020-06)Background During periodontitis, tooth-supporting alveolar bone is resorbed when there is an increased expression of the pro-osteolytic factor termed receptor activator of nuclear factor kappa B ligand (RANKL), which is ... -
Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes
(MDPI, 2020-05)The adverse environmental conditions found in the periodontium during periodontitis pathogenesis stimulate local autophagy responses, mainly due to a continuous inflammatory response against the dysbiotic subgingival ... -
IL-22-expressing CD4(+)AhR(+) T lymphocytes are associated with RANKL-mediated alveolar bone resorption during experimental periodontitis
(Blackwell Munksgaard, 2019-10)Background and Objective Over the past few years, the importance of interleukin-22 (IL-22) and T-helper (Th)22 lymphocytes in the pathogenesis of periodontitis has become apparent; however, there are still aspects that are ... -
MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content
(Elsevier BV, 2017)MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in ... -
Axonal degeneration induced by glutamate excitotoxicity is mediated by necroptosis
(Company of Biologists Ltd, 2018)Neuronal excitotoxicity induced by glutamate leads to cell death and functional impairment in a variety of central nervous system pathologies. Glutamate-mediated excitotoxicity triggers neuronal apoptosis in the cell soma ...