Centro de Biología Integrativa (CBI): Envíos recientes
Mostrando ítems 81-88 de 88
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Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis
(NATL ACAD SCIENCES, 2018)Abnormal modifications to mutant superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS). Misfolding of wild-type SOD1 (SOD1(WT)) is also observed in postmortem tissue of a subset of ... -
Unraveling the role of motoneuron autophagy in ALS
(TAYLOR & FRANCIS INC, 2018)In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. Genetic evidence indicates that mutations in autophagy-regulatory ... -
Origin of axonal proteins: Is the axon-schwann cell unit a functional syncytium?
(CIENCIAS, 2016)The structural homeostasis is challenging for neurons, whose axons extend up to meters in large animals, and the axoplasmic mass reaches over a thousand times that of the cell body. Thus, the protein demand may overcome ... -
Injury to the nervous system: A look into the ER
(CIENCIAS, 2016)Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex ... -
Bursting the unfolded protein response accelerates axonal regeneration
(CIENCIAS, 2016)Peripheral neuropathies refer to a group of conditions in which the peripheral nervous system (PNS) is damaged. These pathological state are are associated with weakness, pain, and loss of motor and sensory control. More ... -
Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury
(CIENCIAS, 2016)Neuropathic pain following peripheral nerve injury is associated with hyperexcitability in damaged myelinated sensory axons, which begins to normalise over time. We investigated the composition and distribution of ... -
Schwann cell and axon: An interlaced unit—From action potential to phenotype expression
(Facultad de Ciencias, 2016)Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence ... -
Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration
(Chile. Universidad Mayor, 2017-11)Wallerian degeneration is an active program tightly associated with axonal degeneration, required for axonal regeneration and functional recovery after nerve damage. Here we provide a functional molecular foundation for ...