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Pleione: A tool for statistical and multi-objective calibration of Rule-based models
(NATURE PUBLISHING GROUP, 2019)
Mathematical models based on Ordinary Differential Equations (ODEs) are frequently used to describe and simulate biological systems. Nevertheless, such models are often difficult to understand. Unlike ODE models, Rule-Based ...
Identification of Modules With Similar Gene Regulation and Metabolic Functions Based on Co-expression Data
(FRONTIERS MEDIA SA, 2019)
Biological systems respond to environmental perturbations and to a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. In particular, a wide variety of gene co-expression ...
Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
(Chile. Universidad Mayor, 2019-10-16)
Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ...
The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains
(Public Library of Science, 2019-12-19)
In this work, we describe a systematic comparative genomic analysis of promiscuous domains in genomes of Bacteria and Archaea. A quantitative measure of domain promiscuity, the weighted domain architecture score (WDAS), ...
Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans
(NATURE PUBLISHING GROUP, 2019)
Whole human genome sequencing initiatives help us understand population history and the basis of genetic diseases. Current data mostly focuses on Old World populations, and the information of the genomic structure of Native ...
Intermediate-Salinity Systems at High Altitudes in the Peruvian Andes Unveil a High Diversity and Abundance of Bacteria and Viruses
(MDPI, 2019)
Intermediate-salinity environments are distributed around the world. Here, we present a snapshot characterization of two Peruvian thalassohaline environments at high altitude, Maras and Acos, which provide an excellent ...
Tracing the phylogenetic history of the Crl regulon through the Bacteria and Archaea genomes
(BMC, 2019)
Background: Crl, identified for curli production, is a small transcription factor that stimulates the association of the sigma(S) factor (RpoS) with the RNA polymerase core through direct and specific interactions, increasing ...
Effect of CO2 Concentration on Uptake and Assimilation of Inorganic Carbon in the Extreme Acidophile Acidithiobacillus ferrooxidans
(FRONTIERS MEDIA SA, 2019)
This study was motivated by surprising gaps in the current knowledge of microbial inorganic carbon (Ci) uptake and assimilation at acidic pH values (pH < 3). Particularly striking is the limited understanding of the ...
ATP6V(0)d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis
(PUBLIC LIBRARY SCIENCE, 2019)
V-ATPases are part of the membrane components of pathogen-containing vacuoles, although their function in intracellular infection remains elusive. In addition to organelle acidification, V-ATPases are alternatively implicated ...
Non-lysosomal Activation in Macrophages of Atlantic Salmon (Salmo salar) After Infection With Piscirickettsia salmonis
(FRONTIERS MEDIA SA, 2019)
Piscirickettsia salmonis is a facultative intracellular pathogen and etiological agent of the systemic disease salmonid rickettsial septicemia. It has been suggested that P salmonis is able to survive in host macrophages, ...