Mostrando ítems 41-60 de 78

    • Single-Nucleotide Polymorphisms (SNP) Mining and Their Effect on the Tridimensional Protein Structure Prediction in a Set of Immunity-Related Expressed Sequence Tags (EST) in Atlantic Salmon (Salmo salar) 

      Vallejos-Vidal, Eva; Reyes-Cerpa, Sebastián [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Maisey, Kevin; Yañez, José M.; Valenzuela, Héctor; Cea, Pablo A.; Castro-Fernández, Víctor; Tort, Lluis; Sandino, Ana M.; Imarai, Mónica; Reyes-López, Felipe E. (Frontiers Media S.A., 2020-02-27)
      Single-nucleotide polymorphisms (SNPs) are single genetic code variations considered one of the most common forms of nucleotide modifications. Such SNPs can be located in genes associated to immune response and, therefore, ...
    • Interleukin-35 inhibits alveolar bone resorption by modulating the Th17/Treg imbalance during periodontitis 

      Cafferata, Emilio A.; Terraza-Aguirre, Claudia; Barrera, Romina; Faúndez, Nicolás; González, Nicolás; Rojas, Carolina; Melgar-Rodríguez, Samanta; Hernández, Marcela; Carvajal, Paola; Cortez, Cristian [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; González, Fermin E.; Covarrubias, Cristian; Vernal, Rolando (Blackwell Munksgaard, 2020-04)
      Aim T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting ...
    • Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus 

      Vergara, Eva; Neira, Gonzalo; González, Carolina [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Cortez, Diego; Dopson, Mark; Holmes, David S. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (MDPI Multidisciplinary Digital Publishing Institute, 2020-04)
      Organisms that thrive in extremely acidic environments (<= pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely ...
    • A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues 

      Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Li, Yong; Martonfalvi, Zsolt; Tapia-Rojo, Rafael; Unger, Andreas; Fernández-Trasancos, Angel; Herrero-Galán, Elías; Velázquez-Carreras, Diana; Fernández, Julio M.; Linke, Wolfgang A.; Alegre-Cebollada, Jorge (Nature Publishing Group, 2020-04-28)
      Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. However, testing these mechanical hypotheses on proteins ...
    • Draft Genome Sequence of Blautia luti DSM 14534(T), Isolated from Human Stool 

      Ortiz, Rodrigo L.; Melis-Arcos, Felipe; Covarrubias, Paulo C.; Ugalde, Juan A.; Apte, Zachary S.; Pérez-Donoso, José; Cárdenas, Juan P. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Almonacid, Daniel E. (Chile. Universidad Mayor, 2020-05)
      Here, we report the draft sequence of Blautia luti strain DSM 14534T, originally isolated from human feces. This draft contains 74 contigs, comprising 3,718,760 bp with a G+C content of 42.87%. The annotated draft contains ...
    • Unlocking Survival Mechanisms for Metal and Oxidative Stress in the Extremely Acidophilic, Halotolerant Acidihalobacter Genus 

      Khaleque, Himel Nahreen; Fathollazadeh, Homayoun; González, Carolina [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Shafique, Raihan; Kaksonen, Anna H.; Holmes, David S. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Watkin, Elizabeth L.J. (MDPI Multidisciplinary Digital Publishing Institute, 2020-11-24)
      Microorganisms used for the biohydrometallurgical extraction of metals from minerals must be able to survive high levels of metal and oxidative stress found in bioleaching environments. The Acidihalobacter genus consists ...
    • Interfering with the Folding of Group A Streptococcal pili Proteins 

      Contreras, Fernanda [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Rivas-Pardo, Jaime Andrés [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (Chile. Universidad Mayor, 2020-05-20)
      Gram-positive bacteria use their adhesive pili to attach to host cells during early stages of a bacterial infection. These extracellular hair-like appendages experience mechanical stresses of hundreds of picoNewtons; ...
    • Nutrient dose-responsive transcriptome changes driven by Michaelis Menten kinetics underlie plant growth rates 

      Swift, Joseph; Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Araus, Viviana; Gutiérrez, Rodrigo A.; Coruzzi, Gloria M. (National Academy of Sciences, 2020-06-09)
      An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes ...
    • Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade 

      Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Schinke, Anna-Lena; Brooks, Matthew D.; Pasquino, Angelo; Leonelli, Lauriebeth; Varala, Kranthi; Safi, Alaeddine; Krouk, Gabriel; Krapp, Anne; Coruzzi, Gloria M. (Nature Publishing Group, 2020-03-02)
      Dynamic reprogramming of gene regulatory networks (GRNs) enables organisms to rapidly respond to environmental perturbation. However, the underlying transient interactions between transcription factors (TFs) and genome-wide ...
    • A balancing act: how plants integrate nitrogen and water signals 

      Araus, Viviana; Swift, Joseph; Alvarez, Jose M. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henry, Amelia; Coruzzi, Gloria M. (Oxford University Press, 2020-07-25)
      Nitrogen (N) and water (W) are crucial inputs for plant survival as well as costly resources for agriculture. Given their importance, the molecular mechanisms that plants rely on to signal changes in either N or W status ...
    • Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion 

      Kalempa Demeu, Lara Maria; Soares, Rodrigo Jahn; Miranda, Juliana Severo; Pacheco-Lugo, Lisandro A.; Oliveira, Kelin Goncalves; Cortez Plaza, Cristian Andres [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Billiald, Philippe; de Moura, Juliana Ferreira; Yoshida, Nobuko; Alvarenga, Larissa Magalhaes; DaRocha, Wanderson Duarte (Chile. Universidad Mayor, 2019-10-16)
      Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is ...
    • Draft genome of Chilean honeybee (Apis mellifera) gut strain Lactobacillus kunkeei MP2 

      Olmos, Alejandro [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Henríquez-Piskulich, Patricia [Ceapi Mayor, Universidad Mayor, Chile]; Sanchez, Carolina [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Rojas-Herrera, Marcelo [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Moreno-Pino, Mario [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Gómez, Marcela [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Rodríguez Da Silva, Rafael [CEAPI Mayor, Universidad Mayor, Chile]; Maracaja-Coutinho, Vinicius [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile]; Aldea, Patricia [CEAPI Mayor, Universidad Mayor, Chile]; Trombert, Annette N. [Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Chile] (American Society for Microbiology, 2014)
      Here, we report the first draft genome sequence of Lactobacillus kunkeei strain MP2, isolated from a Chilean honeybee gut. The sequenced genome has a total size of 1.58 Mb distributed into 44 contigs and 1,356 protein-coding ...
    • Inhibitory effect of serotype a of Aggregatibacter actinomycetemcomitans on the increased destructive potential of serotype b 

      Cortez, Cristián [Univ Mayor, Ctr Genom & Bioinformat, Fac Sci, Santiago, Chile]; Rojas, Leticia; Melgar-Rodríguez, Samanta; Díaz-Zuniga, Jaime; Alvarez, Carla; Monasterio, Gustavo; Rojas, Carolina; Cafferata, Emilio A.; Hernández, Marcela; Carvajal, Paola; Vernal, Rolando (WILEY, 2020)
      Objective The serotype b of Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) induces higher cytokine production in dendritic cells (DCs) compared with the other serotypes. However, this increased immunostimulatory ...
    • Pleione: A tool for statistical and multi-objective calibration of Rule-based models 

      Martin, Alberto J. M. [Univ Mayor, Fac Ciencias, Network Biol Lab, Ctr Genom & Bioinformat]; Santibáñez, Rodrigo [Univ Mayor, Fac Ciencias, Network Biol Lab, Ctr Genom & Bioinformat]; Garrido, Daniel (NATURE PUBLISHING GROUP, 2019)
      Mathematical models based on Ordinary Differential Equations (ODEs) are frequently used to describe and simulate biological systems. Nevertheless, such models are often difficult to understand. Unlike ODE models, Rule-Based ...
    • Identification of Modules With Similar Gene Regulation and Metabolic Functions Based on Co-expression Data 

      Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Galán-Vásquez, Edgardo (FRONTIERS MEDIA SA, 2019)
      Biological systems respond to environmental perturbations and to a large diversity of compounds through gene interactions, and these genetic factors comprise complex networks. In particular, a wide variety of gene co-expression ...
    • Whole Genome Sequence, Variant Discovery and Annotation in Mapuche-Huilliche Native South Americans 

      Vizoso, Paula [Univ Mayor, Fac Ciencias, Ctr Propagac Conservac Vegetal CEPROVEG, Santiago, Chile]; Vidal, Elena A. [Univ Mayor, Fac Ciencias, Ctr Geneim Bioinformat, Santiago, Chile]; Moyano, Tomás C.; Bustos, Bernabe, I; Pérez-Palma, Eduardo; Moraga, Carol; Riveras, Eleodoro; Montecinos, Alejandro; Azocar, Lorena; Soto, Daniela C.; Vidal, Mabel; Di Genoval, Alex; Puschel, Klaus; Nurnberg, Peter; Buch, Stephan; Hampe, Jochen; Allende, Miguel L.; Cambiazo, Veronica; González, Mauricio; Hodar, Christian; Montecino, Martin; Muñoz-Espinoza, Claudia; Orellana, Ariel; Reyes-Jara, Angelica; Travisanyl, Dante; Moraga, Mauricio; Eyheramendy, Susana; Maass, Alejandro; De Ferrari, Giancarlo, V; Mique, Juan Francisco; Gutiérrez, Rodrigo A. (NATURE PUBLISHING GROUP, 2019)
      Whole human genome sequencing initiatives help us understand population history and the basis of genetic diseases. Current data mostly focuses on Old World populations, and the information of the genomic structure of Native ...
    • Intermediate-Salinity Systems at High Altitudes in the Peruvian Andes Unveil a High Diversity and Abundance of Bacteria and Viruses 

      Pérez-Rueda, Ernesto [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat]; Gildardo Castelan-Sánchez, Hugo; Elorrieta, Paola; Romoacca, Pedro; Linan-Torres, Arturo; Luis Sierra, Jose; Vera, Ingrid; Alberto Batista-Garcia, Ramon; Tenorio-Salgado, Silvia; Lizama-Uc, Gabriel; Antonieta Quispe-Ricalde, Maria; Davila-Ramos, Sonia (MDPI, 2019)
      Intermediate-salinity environments are distributed around the world. Here, we present a snapshot characterization of two Peruvian thalassohaline environments at high altitude, Maras and Acos, which provide an excellent ...
    • Tracing the phylogenetic history of the Crl regulon through the Bacteria and Archaea genomes 

      Pérez-Rueda, E. [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Santos-Zavaleta, A.; Sánchez-Pérez, M.; Velazquez-Ramírez, D. A.; Collado-Vides, J. (BMC, 2019)
      Background: Crl, identified for curli production, is a small transcription factor that stimulates the association of the sigma(S) factor (RpoS) with the RNA polymerase core through direct and specific interactions, increasing ...
    • Effect of CO2 Concentration on Uptake and Assimilation of Inorganic Carbon in the Extreme Acidophile Acidithiobacillus ferrooxidans 

      Holmes, David S.[Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Esparza, Mario; Jedlicki, Eugenia; González, Carolina; Dopson, Mark (FRONTIERS MEDIA SA, 2019)
      This study was motivated by surprising gaps in the current knowledge of microbial inorganic carbon (Ci) uptake and assimilation at acidic pH values (pH < 3). Particularly striking is the limited understanding of the ...
    • ATP6V(0)d2 controls Leishmania parasitophorous vacuole biogenesis via cholesterol homeostasis 

      Cortez, Cristián [Univ Mayor, Fac Ciencias, Ctr Genom & Bioinformat, Santiago, Chile]; Pessoa, Carina Carraro; Reis, Luiza Campos; Ramos-Sánchez, Eduardo Milton; Orikaza, Cristina Mary; de Castro Levatti, Erica Valadares; Benites Badaro, Ana Carolina; da Silva Yamamoto, Joyce Umbelino; D'Almeida, Vania; Goto, Hiro; Mortara, Renato Arruda; Real, Fernando (PUBLIC LIBRARY SCIENCE, 2019)
      V-ATPases are part of the membrane components of pathogen-containing vacuoles, although their function in intracellular infection remains elusive. In addition to organelle acidification, V-ATPases are alternatively implicated ...


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