Repositorio UMAYOR: Envíos recientes
Mostrando ítems 3461-3480 de 7669
-
Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein
(IMPACT JOURNALS LLC, 2020)Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. ... -
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
(BMC, 2019)BackgroundAmyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. ... -
MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells
(TAYLOR & FRANCIS INC, 2019)The interruption of endoplasmic reticulum (ER)-mitochondrial Ca2+ communication induces a bioenergetic crisis characterized by an increase of MTOR-independent AMPK-dependent macroautophagic/autophagic flux, which is not ... -
Cómo se desarrolla el proceso enseñanza-aprendizaje de los estudiantes de primero y segundo año básico que participan del Programa de Integración Escolar, a la luz de la implementación del Decreto N°83/2015
(Chile. Universidad Mayor, 2018)En un enfoque inclusivo que atiende las necesidades de cada estudiante, nace la condición de dar respuesta a las demandas para brindar a todas y todos los estudiantes una educación escolar adecuada y de calidad en un ... -
Diseño de un protocolo de Evaluación/Detección de tartamudez infantil (PEDTI)
(Chile. Universidad Mayor, 2017)La tartamudez es un trastorno de la comunicación que afecta la fluidez del habla caracterizada por repeticiones, interrupciones, prolongaciones de sonidos, movimientos de cara y cuerpo acompañados de tensión y que puede ... -
Gadolinium Chloride Rescues Niemann-Pick Type C Liver Damage
(MDPI, 2018)Niemann-Pick type C (NPC) disease is a rare neurovisceral cholesterol storage disorder that arises from loss of function mutations in the NPC1 or NPC2 genes. Soon after birth, some patients present with an aggressive ... -
Improved ontology for eukaryotic single-exon coding sequences in biological databases
(OXFORD UNIV PRESS, 2018)Efficient extraction of knowledge from biological data requires the development of structured vocabularies to unambiguously define biological terms. This paper proposes descriptions and definitions to disambiguate the term ... -
Structure-Activity Relationships Based on 3D-QSAR CoMFA/CoMSIA and Design of Aryloxypropanol-Amine Agonists with Selectivity for the Human 3-Adrenergic Receptor and Anti-Obesity and Anti-Diabetic Profiles
(MDPI, 2018)The wide tissue distribution of the adrenergic 3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there ... -
A highly stable black phosphorene nanocomposite for voltammetric detection of clenbuterol
(SPRINGER WIEN, 2018)A nanocomposite was prepared from graphene-like two-dimensional black phosphorene (BP, an allotrope of phosphorus) and nafion (Nf) treated with isopropanol (IP). A glassy carbon electrode (GCE) modified with this nanocomposite ... -
Coherent population trapping with a controlled dissipation: applications in optical metrology
(IOP PUBLISHING LTD, 2018)We analyze the properties of a pulsed coherent population trapping protocol that uses a controlled decay from the excited state in a Lambda-level scheme. We study this problem analytically and numerically and find regimes ... -
Highly efficient cooling of mechanical resonator with square pulse drives
(OPTICAL SOC AMER, 2018)Ground state cooling of mechanical resonator is a way to generate macroscopic quantum states. Here we present a study of optomechanical cooling under the drive of square pulses without smooth profile. By illustrating the ... -
Ground-state cooling of a nanomechanical oscillator with N spins
(AMER PHYSICAL SOC, 2018)It is typical of modern quantum technologies employing nanomechanical oscillators to demand few mechanical quantum excitations, for instance, to prolong coherence times of a particular task or to engineer a specific ... -
Optical qubit generation via atomic postselection in a Ramsey interferometer
(IOP PUBLISHING LTD, 2018)We propose a realizable experimental scheme to prepare a superposition of the vacuum and one-photon states using a typical cavity QED-setup. This is different from previous schemes, where the superposition state of the ... -
One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor
(ROYAL SOC CHEMISTRY, 2018-01-21)A layer-by-layer (LBL) assembly was employed for preparing multilayer thin films with a controlled architecture and composition. In this study, we report the one-step coelectrodeposition-assisted LBL assembly of both gold ... -
Experimental and Computational Characterization of the Interaction between Gold Nanoparticles and Polyamidoamine Dendrimers
(AMER CHEMICAL SOC, 2018)Dendrimers provide a means to control the synthesis of gold nanoparticles and stabilize their suspensions. However, design of improved dendrimers for this application is hindered by a lack of understanding how the dendrimers ... -
Mechanical Properties Obtained by Indentation of Hollow Pd Nanoparticles
(AMER CHEMICAL SOC, 2018)Palladium nanoparticles are technologically important for catalysis, hydrogen storage, and many other applications. Here, we investigate the mechanical properties of Pd hollow nanoparticles of different sizes and thicknesses ... -
Using Femtosecond Laser Irradiation To Grow the Belly of Gold Nanorods
(AMER CHEMICAL SOC, 2018)Irradiation of gold nanorods can lead to the formation of several new nanostructures. One of the most interesting among them are phi-shaped rods, a stable intermediate shape in the rod-to-sphere conversion process, but not ... -
Correction: One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor
(ROYAL SOC CHEMISTRY, 2018-02-07)Correction for ‘One-step coelectrodeposition-assisted layer-by-layer assembly of gold nanoparticles and reduced graphene oxide and its self-healing three-dimensional nanohybrid for an ultrasensitive DNA sensor’ by Jayakumar ... -
Polyaniline Based Materials as a Method to Eliminate Haloanisoles in Spirits Beverages
(AMER CHEMICAL SOC, 2018)In this research, the abilities of two polyaniline-based materials (PANI-EB and PANI-ES) were evaluated as potential fining agents to eliminate 2,4,6-trichloroanisole (TCA) and 2,4,6-tribromoanisole (TBA). The results ... -
Phenology determines the robustness of plant-pollinator networks
(NATURE PUBLISHING GROUP, 2018)Plant-pollinator systems are essential for ecosystem functioning, which calls for an understanding of the determinants of their robustness to environmental threats. Previous studies considering such robustness have focused ...